DNA markers associated with general and specific cognitive abilities

Stephen A. Petrill, Robert Plomin, Gerald E. McClearn, Deborah L. Smith, Sylvia Vignetti, Michael J. Chorney, Karen Chorney, Lee A. Thompson, Douglas K. Detterman, Camilla Benbow, David Lubinski, Joanna Daniels, Michael J. Owen, Peter McGuffin

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Multivariate quantitative genetic research suggests a hierarchical model of cognitive abilities where genetic effects are largely general, cutting across most cognitive abilities. Some genetic effects, however, are specific to certain cognitive abilities. These results lead to a hypothesis for molecular genetic research: Although most genes associated with one cognitive ability will be related to other cognitive abilities, some genes will be specific to a particular cognitive ability. The current research explored this hypothesis in an analysis of data in specific cognitive abilities from 86 children from 6 to 12 years of age from a larger allelic association study of general cognitive ability. Eight DNA markers were entered simultaneously in separate multiple regression analyses predicting each of four specific cognitive ability factors (Verbal, Spatial, Perceptual Speed, Memory), as well as WISC-R subtest scores. Four marjers (CTGB33, EST00083, HLA, and SOD2) showed similar effects across the cognitive ability scales, suggesting that they are related to general cognitive ability (g). These associations became negligible when the effects of 'g' (WISC-R IQ) were removed. Three markers (ADH5, DM, and NGFB) continued to be significantly associated with specific cognitive ability scales after the effects of 'g' were removed. Although preliminary, these molecular genetic results support the hierarchical model predicted by quantitative genetic research.

Original languageEnglish (US)
Pages (from-to)191-203
Number of pages13
JournalIntelligence
Volume23
Issue number3
DOIs
StatePublished - Nov 1 1996

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Aptitude
Genetic Markers
Genetic Research
Cognitive Ability
Molecular Biology
Genes
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Petrill, S. A., Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., ... McGuffin, P. (1996). DNA markers associated with general and specific cognitive abilities. Intelligence, 23(3), 191-203. https://doi.org/10.1016/S0160-2896(96)90003-3
Petrill, Stephen A. ; Plomin, Robert ; McClearn, Gerald E. ; Smith, Deborah L. ; Vignetti, Sylvia ; Chorney, Michael J. ; Chorney, Karen ; Thompson, Lee A. ; Detterman, Douglas K. ; Benbow, Camilla ; Lubinski, David ; Daniels, Joanna ; Owen, Michael J. ; McGuffin, Peter. / DNA markers associated with general and specific cognitive abilities. In: Intelligence. 1996 ; Vol. 23, No. 3. pp. 191-203.
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Petrill, SA, Plomin, R, McClearn, GE, Smith, DL, Vignetti, S, Chorney, MJ, Chorney, K, Thompson, LA, Detterman, DK, Benbow, C, Lubinski, D, Daniels, J, Owen, MJ & McGuffin, P 1996, 'DNA markers associated with general and specific cognitive abilities', Intelligence, vol. 23, no. 3, pp. 191-203. https://doi.org/10.1016/S0160-2896(96)90003-3

DNA markers associated with general and specific cognitive abilities. / Petrill, Stephen A.; Plomin, Robert; McClearn, Gerald E.; Smith, Deborah L.; Vignetti, Sylvia; Chorney, Michael J.; Chorney, Karen; Thompson, Lee A.; Detterman, Douglas K.; Benbow, Camilla; Lubinski, David; Daniels, Joanna; Owen, Michael J.; McGuffin, Peter.

In: Intelligence, Vol. 23, No. 3, 01.11.1996, p. 191-203.

Research output: Contribution to journalArticle

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Petrill SA, Plomin R, McClearn GE, Smith DL, Vignetti S, Chorney MJ et al. DNA markers associated with general and specific cognitive abilities. Intelligence. 1996 Nov 1;23(3):191-203. https://doi.org/10.1016/S0160-2896(96)90003-3