DNA-mediated charge transport in redox sensing and signaling

Joseph C. Genereux, Amie K. Boal, Jacqueline K. Barton

Research output: Contribution to journalReview article

136 Citations (Scopus)

Abstract

(Figure Presented) The transport of charge through the DNA base-pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this chemistry that have been elucidated and how this chemistry may be utilized within the cell. The shallow distance dependence associated with these redox reactions permits DNA-mediated signaling over long molecular distances in the genome and facilitates the activation of redox-sensitive transcription factors globally in response to oxidative stress. The long-range funneling of oxidative damage to sites of low oxidation potential in the genome also may provide a means of protection within the cell. Furthermore, the sensitivity of DNA charge transport to perturbations in base-pair stacking, as may arise with base lesions and mismatches, may be used as a route to scan the genome for damage as a first step in DNA repair. Thus, the ability of double-helical DNA in mediating redox chemistry at a distance provides a natural mechanism for redox sensing and signaling in the genome.

Original languageEnglish (US)
Pages (from-to)891-905
Number of pages15
JournalJournal of the American Chemical Society
Volume132
Issue number3
DOIs
StatePublished - Feb 12 2010

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Oxidation-Reduction
Charge transfer
DNA
Genes
Genome
Base Pairing
Transcription factors
Oxidative stress
Cytoprotection
Redox reactions
DNA Repair
Oxidative Stress
Repair
Transcription Factors
Chemical activation
Oxidation

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

Cite this

Genereux, Joseph C. ; Boal, Amie K. ; Barton, Jacqueline K. / DNA-mediated charge transport in redox sensing and signaling. In: Journal of the American Chemical Society. 2010 ; Vol. 132, No. 3. pp. 891-905.
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DNA-mediated charge transport in redox sensing and signaling. / Genereux, Joseph C.; Boal, Amie K.; Barton, Jacqueline K.

In: Journal of the American Chemical Society, Vol. 132, No. 3, 12.02.2010, p. 891-905.

Research output: Contribution to journalReview article

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AU - Genereux, Joseph C.

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AU - Barton, Jacqueline K.

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N2 - (Figure Presented) The transport of charge through the DNA base-pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this chemistry that have been elucidated and how this chemistry may be utilized within the cell. The shallow distance dependence associated with these redox reactions permits DNA-mediated signaling over long molecular distances in the genome and facilitates the activation of redox-sensitive transcription factors globally in response to oxidative stress. The long-range funneling of oxidative damage to sites of low oxidation potential in the genome also may provide a means of protection within the cell. Furthermore, the sensitivity of DNA charge transport to perturbations in base-pair stacking, as may arise with base lesions and mismatches, may be used as a route to scan the genome for damage as a first step in DNA repair. Thus, the ability of double-helical DNA in mediating redox chemistry at a distance provides a natural mechanism for redox sensing and signaling in the genome.

AB - (Figure Presented) The transport of charge through the DNA base-pair stack offers a route to carry out redox chemistry at a distance. Here we describe characteristics of this chemistry that have been elucidated and how this chemistry may be utilized within the cell. The shallow distance dependence associated with these redox reactions permits DNA-mediated signaling over long molecular distances in the genome and facilitates the activation of redox-sensitive transcription factors globally in response to oxidative stress. The long-range funneling of oxidative damage to sites of low oxidation potential in the genome also may provide a means of protection within the cell. Furthermore, the sensitivity of DNA charge transport to perturbations in base-pair stacking, as may arise with base lesions and mismatches, may be used as a route to scan the genome for damage as a first step in DNA repair. Thus, the ability of double-helical DNA in mediating redox chemistry at a distance provides a natural mechanism for redox sensing and signaling in the genome.

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