DNA synthesis in the anterior pituitary of the male rat: Effect of castration and photoperiod

W. C. Hymer, Andrea Marie Mastro, Elaine Griswold

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Castration increased incorporation of tritiated thymidine into total DNA in the anterior pituitary gland. Furthermore, there was a threefold increase in the percentage of labeled basophils 1 month after castration. Exposure of rats to constant light or dark also changed DNA synthesis; these changes depended on age of the animal and on exposure length. The results reflect physiologically induced mitotic activity in specific classes of pituitary cells and further suggest that neuroendocrine mechanisms may be inolved in control of cell turnover in the gland.

Original languageEnglish (US)
Pages (from-to)1629-1631
Number of pages3
JournalScience
Volume167
Issue number3925
DOIs
StatePublished - Jan 1 1970

All Science Journal Classification (ASJC) codes

  • General

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