DNA synthesis is not required for the commitment of murine erythroleukemia cells

Robert Levenson, Joseph Kernen, Alberto Mitrani, David Housman

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

We have assessed the relationship between DNA synthesis and the differentiation of MEL cells induced by DMSO. Under conditions where the rate of incorporation of 3H-deoxyadenosine into DNA was inhibited by 99%, the rate at which MEL cells become committed to terminal erythroid differentiation was identical to that of a culture treated with inducer alone. We conclude that commitment of MEL cells does not require concomitant DNA synthesis.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalDevelopmental biology
Volume74
Issue number1
DOIs
StatePublished - Jan 1980

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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