Do antioxidants still have a role in the prevention of human cancer?

Mack Ruffin, C. L. Rock

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

Antioxidants are components of diet that are involved in DNA and cell maintenance and repair. Dietary antioxidants include carotenoids, vitamin C, vitamin E, and selenium. Across a variety of cancers, the observational studies have inconsistent results with respect to the relationship shown of specific dietary intake or serum levels of antioxidants and risk of certain cancers. The results of the micronutrient supplement trials clearly do not support a reductionist approach to promoting regression of precancerous lesions or prevention of new cancer, except in a few cancers and specific populations. The ability of the antioxidant micronutrients to influence the risk for tissue injury and for cancer, mediated by their antioxidant activities, remains hypothetical.

Original languageEnglish (US)
Pages (from-to)306-313
Number of pages8
JournalCurrent Oncology Reports
Volume3
Issue number4
StatePublished - Jan 1 2001

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Antioxidants
Micronutrients
Neoplasms
Carotenoids
Selenium
Vitamin E
Ascorbic Acid
Observational Studies
Maintenance
Diet
DNA
Wounds and Injuries
Serum
Population

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

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Do antioxidants still have a role in the prevention of human cancer? / Ruffin, Mack; Rock, C. L.

In: Current Oncology Reports, Vol. 3, No. 4, 01.01.2001, p. 306-313.

Research output: Contribution to journalReview article

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