Do antipsychotics limit disability in schizophrenia A naturalistic comparative study in the community

Jagadisha Thirthalli, Basappa K. Venkatesh, Magadi N. Naveen, Ganesan Venkatasubramanian, Udupi Arunachala, Kengeri V. Kishore Kumar, Bangalore N. Gangadhar

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Though antipsychotics are effective against symptoms of schizophrenia and prevent relapses, their effect on disability has not been studied in a comparative design. Aim: To compare disability of schizophrenia patients receiving continuous antipsychotic treatment with that of those not receiving or receiving irregular treatment in a rural community setting using a naturalistic comparative study design. Patients and Methods: Disability was assessed in 182 schizophrenia patients living in Thirthahalli Taluk of Shimoga District, Karnataka, using Indian Disability Evaluation and Assessment Scale (IDEAS). Fifty patients (27.5%) were receiving regular treatment in the previous 2 years and their disability was assessed for the period when they were on antipsychotics. The remaining 132 patients (72.5%) had off-antipsychotics periods in the previous 2 years and their disability was assessed for the period when they were off-antipsychotics. Results: Patients on antipsychotics had significantly less disability across all domains of disability and in total IDEAS scores. Multivariate regression analysis showed that treatment status predicted disability scores after controlling for the effects of the confounding factors. Different levels of exposure to antipsychotic treatment were associated with different levels of disability. Conclusions: Treatment with antipsychotics is associated with significantly less disability. There is an urgent need to bring schizophrenia patients under the umbrella of treatment.

Original languageEnglish (US)
Pages (from-to)37-41
Number of pages5
JournalIndian Journal of Psychiatry
Volume52
Issue number1
DOIs
StatePublished - Jan 1 2010

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Antipsychotic Agents
Schizophrenia
Disability Evaluation
Therapeutics
Rural Population
Multivariate Analysis
Regression Analysis
Recurrence

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Thirthalli, J., Venkatesh, B. K., Naveen, M. N., Venkatasubramanian, G., Arunachala, U., Kishore Kumar, K. V., & Gangadhar, B. N. (2010). Do antipsychotics limit disability in schizophrenia A naturalistic comparative study in the community. Indian Journal of Psychiatry, 52(1), 37-41. https://doi.org/10.4103/0019-5545.58893
Thirthalli, Jagadisha ; Venkatesh, Basappa K. ; Naveen, Magadi N. ; Venkatasubramanian, Ganesan ; Arunachala, Udupi ; Kishore Kumar, Kengeri V. ; Gangadhar, Bangalore N. / Do antipsychotics limit disability in schizophrenia A naturalistic comparative study in the community. In: Indian Journal of Psychiatry. 2010 ; Vol. 52, No. 1. pp. 37-41.
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Thirthalli, J, Venkatesh, BK, Naveen, MN, Venkatasubramanian, G, Arunachala, U, Kishore Kumar, KV & Gangadhar, BN 2010, 'Do antipsychotics limit disability in schizophrenia A naturalistic comparative study in the community', Indian Journal of Psychiatry, vol. 52, no. 1, pp. 37-41. https://doi.org/10.4103/0019-5545.58893

Do antipsychotics limit disability in schizophrenia A naturalistic comparative study in the community. / Thirthalli, Jagadisha; Venkatesh, Basappa K.; Naveen, Magadi N.; Venkatasubramanian, Ganesan; Arunachala, Udupi; Kishore Kumar, Kengeri V.; Gangadhar, Bangalore N.

In: Indian Journal of Psychiatry, Vol. 52, No. 1, 01.01.2010, p. 37-41.

Research output: Contribution to journalArticle

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N2 - Background: Though antipsychotics are effective against symptoms of schizophrenia and prevent relapses, their effect on disability has not been studied in a comparative design. Aim: To compare disability of schizophrenia patients receiving continuous antipsychotic treatment with that of those not receiving or receiving irregular treatment in a rural community setting using a naturalistic comparative study design. Patients and Methods: Disability was assessed in 182 schizophrenia patients living in Thirthahalli Taluk of Shimoga District, Karnataka, using Indian Disability Evaluation and Assessment Scale (IDEAS). Fifty patients (27.5%) were receiving regular treatment in the previous 2 years and their disability was assessed for the period when they were on antipsychotics. The remaining 132 patients (72.5%) had off-antipsychotics periods in the previous 2 years and their disability was assessed for the period when they were off-antipsychotics. Results: Patients on antipsychotics had significantly less disability across all domains of disability and in total IDEAS scores. Multivariate regression analysis showed that treatment status predicted disability scores after controlling for the effects of the confounding factors. Different levels of exposure to antipsychotic treatment were associated with different levels of disability. Conclusions: Treatment with antipsychotics is associated with significantly less disability. There is an urgent need to bring schizophrenia patients under the umbrella of treatment.

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