Do lampreys have lymphocytes? The Spi evidence

Seikou Shintani, Janos Terzic, Akie Sato, Mirna Saraga-Babic, Colm O'Huigin, Herbert Tichy, Jan Klein

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

It is generally accepted that living jawless vertebrates (lampreys and hagfishes) lack the capability of mounting an adaptive immune response. At the same time, however, there are reports describing histological evidence for the presence in agnathan tissues of lymphocytes, the key players in adaptive immunity. The question therefore arises whether the cells identified morphologically as lymphocytes are true lymphocytes in terms of their genetic developmental program. In this study, evidence is provided that the lampreys express a member of the purine box 1 (PU.1)/spleen focus-forming virus integration B (Spi-B) gene family known to be critically and specifically involved in the differentiation of lymphocytes in jawed vertebrates. The lamprey gene is expressed in the lymphocyte-like cells of the digestive tract and inexplicably also in the ovary.

Original languageEnglish (US)
Pages (from-to)7417-7422
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume97
Issue number13
DOIs
StatePublished - Jun 20 2000

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Lampreys
Lymphocytes
Adaptive Immunity
Vertebrates
Spleen Focus-Forming Viruses
Hagfishes
Virus Integration
Genes
Gastrointestinal Tract
Ovary

All Science Journal Classification (ASJC) codes

  • General

Cite this

Shintani, S., Terzic, J., Sato, A., Saraga-Babic, M., O'Huigin, C., Tichy, H., & Klein, J. (2000). Do lampreys have lymphocytes? The Spi evidence. Proceedings of the National Academy of Sciences of the United States of America, 97(13), 7417-7422. https://doi.org/10.1073/pnas.110505597
Shintani, Seikou ; Terzic, Janos ; Sato, Akie ; Saraga-Babic, Mirna ; O'Huigin, Colm ; Tichy, Herbert ; Klein, Jan. / Do lampreys have lymphocytes? The Spi evidence. In: Proceedings of the National Academy of Sciences of the United States of America. 2000 ; Vol. 97, No. 13. pp. 7417-7422.
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Shintani, S, Terzic, J, Sato, A, Saraga-Babic, M, O'Huigin, C, Tichy, H & Klein, J 2000, 'Do lampreys have lymphocytes? The Spi evidence', Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 13, pp. 7417-7422. https://doi.org/10.1073/pnas.110505597

Do lampreys have lymphocytes? The Spi evidence. / Shintani, Seikou; Terzic, Janos; Sato, Akie; Saraga-Babic, Mirna; O'Huigin, Colm; Tichy, Herbert; Klein, Jan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 13, 20.06.2000, p. 7417-7422.

Research output: Contribution to journalArticle

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