Do lifestyle factors influence colorectal cancer risk in Lynch syndrome?

Fränzel J.B. Van Duijnhoven, Akke Botma, Renate Winkels, Fokko M. Nagengast, Hans F.A. Vasen, Ellen Kampman

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Lynch syndrome (LS) is one of the inherited colorectal cancer (CRC) syndromes and is due to germline mutations in one of the mismatch repair (MMR) genes. Within LS affected-families the expression of the syndrome varies, which suggests that other factors, such as lifestyle factors, have an influence on the LS phenotype. This review gives an overview of studies that assessed the role of lifestyle factors in the development of CRC in LS. Several published studies investigated smoking habits or body fatness (BMI) in relation to colorectal tumours. Those studies fairly consistently suggest that smoking and a high BMI markedly increase the risk of CRC in persons with LS. Other lifestyle factors, such as physical activity, alcohol or diet have not or only scarcely been studied. Lifestyle factors may indeed affect CRC risk in LS. However, more prospective studies with only confirmed MMR gene mutation carriers should be done to further elucidate the role of all lifestyle factors in CRC and in other types of cancer in persons with LS. Information on the role of lifestyle factors in the development of LS-associated cancers may help in establishing lifestyle and dietary recommendations with the ultimate goal of decreasing cancer risk in persons with LS.

Original languageEnglish (US)
Pages (from-to)285-293
Number of pages9
JournalFamilial Cancer
Volume12
Issue number2
DOIs
StatePublished - Jun 1 2013

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Hereditary Nonpolyposis Colorectal Neoplasms
Life Style
Colorectal Neoplasms
DNA Mismatch Repair
Smoking
Neoplasms
Germ-Line Mutation
Genes
Habits
Alcohols
Prospective Studies
Diet
Phenotype
Mutation

All Science Journal Classification (ASJC) codes

  • Genetics
  • Oncology
  • Genetics(clinical)
  • Cancer Research

Cite this

Van Duijnhoven, F. J. B., Botma, A., Winkels, R., Nagengast, F. M., Vasen, H. F. A., & Kampman, E. (2013). Do lifestyle factors influence colorectal cancer risk in Lynch syndrome? Familial Cancer, 12(2), 285-293. https://doi.org/10.1007/s10689-013-9645-8
Van Duijnhoven, Fränzel J.B. ; Botma, Akke ; Winkels, Renate ; Nagengast, Fokko M. ; Vasen, Hans F.A. ; Kampman, Ellen. / Do lifestyle factors influence colorectal cancer risk in Lynch syndrome?. In: Familial Cancer. 2013 ; Vol. 12, No. 2. pp. 285-293.
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Van Duijnhoven, FJB, Botma, A, Winkels, R, Nagengast, FM, Vasen, HFA & Kampman, E 2013, 'Do lifestyle factors influence colorectal cancer risk in Lynch syndrome?', Familial Cancer, vol. 12, no. 2, pp. 285-293. https://doi.org/10.1007/s10689-013-9645-8

Do lifestyle factors influence colorectal cancer risk in Lynch syndrome? / Van Duijnhoven, Fränzel J.B.; Botma, Akke; Winkels, Renate; Nagengast, Fokko M.; Vasen, Hans F.A.; Kampman, Ellen.

In: Familial Cancer, Vol. 12, No. 2, 01.06.2013, p. 285-293.

Research output: Contribution to journalArticle

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Van Duijnhoven FJB, Botma A, Winkels R, Nagengast FM, Vasen HFA, Kampman E. Do lifestyle factors influence colorectal cancer risk in Lynch syndrome? Familial Cancer. 2013 Jun 1;12(2):285-293. https://doi.org/10.1007/s10689-013-9645-8