Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations

A randomized crossover controlled intervention trial

L. Baril-Gravel, M. E. Labonté, P. Couture, M. C. Vohl, A. Charest, V. Guay, D. A. Jenkins, P. W. Connelly, Sheila Grace West, Penny Margaret Kris-Etherton, P. J. Jones, Jennifer Anne Fleming, B. Lamarche

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background and aims: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. Methods and results: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods. Each diet provided 60g/3000kcal of different oils: 1) control corn/safflower oil blend (CornSaff; LA-rich), 2) flax/safflower oil blend (FlaxSaff; ALA-rich), 3) conventional canola oil (Canola; OA-rich), 4) high oleic canola oil (CanolaOleic; highest OA content), 5) DHA-enriched high oleic canola oil (CanolaDHA; OA- and DHA-rich). Gene expression in whole blood cells was assessed in a subset of 62 subjects. CanolaDHA increased plasma adiponectin concentrations compared with the control CornSaff oil treatment (+4.5%, P=0.04) and FlaxSaff (+6.9%, P=0.0008). CanolaDHA also reduced relative expression levels of interleukin (IL). 1B compared with CornSaff and Canola (-11% and -13%, respectively, both P=0.03). High-sensitivity C-reactive protein concentrations were lower after Canola than after FlaxSaff (-17.8%, P=0.047).

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2015

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Docosahexaenoic Acids
Adiponectin
Oleic Acid
Safflower Oil
Oils
alpha-Linolenic Acid
Linoleic Acid
Blood Cells
Diet
Flax
Corn Oil
Abdominal Obesity
Interleukins
C-Reactive Protein
Anti-Inflammatory Agents
Transcription Factors
Fatty Acids
Biomarkers
Gene Expression
canola oil

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Baril-Gravel, L. ; Labonté, M. E. ; Couture, P. ; Vohl, M. C. ; Charest, A. ; Guay, V. ; Jenkins, D. A. ; Connelly, P. W. ; West, Sheila Grace ; Kris-Etherton, Penny Margaret ; Jones, P. J. ; Fleming, Jennifer Anne ; Lamarche, B. / Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations : A randomized crossover controlled intervention trial. In: Nutrition, Metabolism and Cardiovascular Diseases. 2015 ; Vol. 25, No. 1. pp. 52-59.
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abstract = "Background and aims: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. Methods and results: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods. Each diet provided 60g/3000kcal of different oils: 1) control corn/safflower oil blend (CornSaff; LA-rich), 2) flax/safflower oil blend (FlaxSaff; ALA-rich), 3) conventional canola oil (Canola; OA-rich), 4) high oleic canola oil (CanolaOleic; highest OA content), 5) DHA-enriched high oleic canola oil (CanolaDHA; OA- and DHA-rich). Gene expression in whole blood cells was assessed in a subset of 62 subjects. CanolaDHA increased plasma adiponectin concentrations compared with the control CornSaff oil treatment (+4.5{\%}, P=0.04) and FlaxSaff (+6.9{\%}, P=0.0008). CanolaDHA also reduced relative expression levels of interleukin (IL). 1B compared with CornSaff and Canola (-11{\%} and -13{\%}, respectively, both P=0.03). High-sensitivity C-reactive protein concentrations were lower after Canola than after FlaxSaff (-17.8{\%}, P=0.047).",
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Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations : A randomized crossover controlled intervention trial. / Baril-Gravel, L.; Labonté, M. E.; Couture, P.; Vohl, M. C.; Charest, A.; Guay, V.; Jenkins, D. A.; Connelly, P. W.; West, Sheila Grace; Kris-Etherton, Penny Margaret; Jones, P. J.; Fleming, Jennifer Anne; Lamarche, B.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 25, No. 1, 01.01.2015, p. 52-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Docosahexaenoic acid-enriched canola oil increases adiponectin concentrations

T2 - A randomized crossover controlled intervention trial

AU - Baril-Gravel, L.

AU - Labonté, M. E.

AU - Couture, P.

AU - Vohl, M. C.

AU - Charest, A.

AU - Guay, V.

AU - Jenkins, D. A.

AU - Connelly, P. W.

AU - West, Sheila Grace

AU - Kris-Etherton, Penny Margaret

AU - Jones, P. J.

AU - Fleming, Jennifer Anne

AU - Lamarche, B.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background and aims: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. Methods and results: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods. Each diet provided 60g/3000kcal of different oils: 1) control corn/safflower oil blend (CornSaff; LA-rich), 2) flax/safflower oil blend (FlaxSaff; ALA-rich), 3) conventional canola oil (Canola; OA-rich), 4) high oleic canola oil (CanolaOleic; highest OA content), 5) DHA-enriched high oleic canola oil (CanolaDHA; OA- and DHA-rich). Gene expression in whole blood cells was assessed in a subset of 62 subjects. CanolaDHA increased plasma adiponectin concentrations compared with the control CornSaff oil treatment (+4.5%, P=0.04) and FlaxSaff (+6.9%, P=0.0008). CanolaDHA also reduced relative expression levels of interleukin (IL). 1B compared with CornSaff and Canola (-11% and -13%, respectively, both P=0.03). High-sensitivity C-reactive protein concentrations were lower after Canola than after FlaxSaff (-17.8%, P=0.047).

AB - Background and aims: Little is known about the effect of various dietary fatty acids on pro- and anti-inflammatory processes. We investigated the effect of 5 oils containing various amounts of alpha-linolenic acid (ALA), linoleic acid (LA), oleic acid (OA) and docosahexaenoic acid (DHA) on plasma inflammatory biomarkers and expression levels of key inflammatory genes and transcription factors in whole blood cells. Methods and results: In a randomized, crossover controlled nutrition intervention, 114 adult men and women with abdominal obesity and at least one other criterion for the metabolic syndrome consumed 5 experimental isoenergetic diets for 4 weeks each, separated by 4-week washout periods. Each diet provided 60g/3000kcal of different oils: 1) control corn/safflower oil blend (CornSaff; LA-rich), 2) flax/safflower oil blend (FlaxSaff; ALA-rich), 3) conventional canola oil (Canola; OA-rich), 4) high oleic canola oil (CanolaOleic; highest OA content), 5) DHA-enriched high oleic canola oil (CanolaDHA; OA- and DHA-rich). Gene expression in whole blood cells was assessed in a subset of 62 subjects. CanolaDHA increased plasma adiponectin concentrations compared with the control CornSaff oil treatment (+4.5%, P=0.04) and FlaxSaff (+6.9%, P=0.0008). CanolaDHA also reduced relative expression levels of interleukin (IL). 1B compared with CornSaff and Canola (-11% and -13%, respectively, both P=0.03). High-sensitivity C-reactive protein concentrations were lower after Canola than after FlaxSaff (-17.8%, P=0.047).

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