Does a preexisting anxiety disorder predict response to paroxetine in irritable bowel syndrome?

Prakash S. Masand, Sanjay Gupta, Thomas L. Schwartz, David Kaplan, Subhdeep Virk, Ahmad Hameed, Kari Lockwood

Research output: Contribution to journalArticle

16 Scopus citations


Irritable bowel syndrome (IBS) is the most common disorder in patients seen by gastroenterologists. Twenty subjects with IBS diagnosed with the Rome criteria were treated for 12 weeks with 20-40 mg/day of paroxetine (mean dose = 31 mg/day). At baseline, 10 patients had a lifetime history of an anxiety disorder, and 10 patients did not have such a history. Both groups had similar improvement in abdominal pain, constipation, diarrhea, incomplete emptying, and bloating/abdominal distension. Paroxetine was very well tolerated.

Original languageEnglish (US)
Pages (from-to)451-455
Number of pages5
Issue number6
StatePublished - Jan 1 2002


All Science Journal Classification (ASJC) codes

  • Arts and Humanities (miscellaneous)
  • Applied Psychology
  • Psychiatry and Mental health

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