Does tea prevent cancer? Evidence from laboratory and human intervention studies

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Tea (Camellia sinensis) is a widely consumed beverage and has been extensively studied for its cancer-preventive activity. Both the polyphenolic constituents as well as the caffeine in tea have been implicated as potential cancer-preventive compounds; the relative importance seems to depend on the cancer type. Green tea and the green tea catechin have been shown to inhibit tumorigenesis at a number of organ sites and to be effective when administered either during the initiation or postinitiation phases of carcinogenesis. Black tea, although not as well studied as green tea, has also shown cancerpreventive effects in laboratory models. A number of potential mechanisms have been proposed to account for the cancer-preventive effects of tea, including modulation of phase II metabolism, alterations in redox environment, inhibition of growth factor signaling, and others. In addition to the laboratory studies, there is a growing body of human intervention studies suggesting that tea can slow cancer progression and modify biomarkers relevant to carcinogenesis. Although available data are promising, many questions remain with regard to the dose-response relations of tea constituents in various models, the primary mechanisms of action, and the potential for combination chemoprevention strategies that involve tea as well as other dietary or pharmaceutical agents. The present review examines the available data from laboratory animal and human intervention studies on tea and cancer prevention. These data were evaluated, and areas for further research are identified.

Original languageEnglish (US)
Pages (from-to)1667S-1675S
JournalAmerican Journal of Clinical Nutrition
Volume98
Issue number6
DOIs
StatePublished - Dec 1 2013

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Tea
Neoplasms
Carcinogenesis
Camellia sinensis
Catechin
Beverages
Chemoprevention
Laboratory Animals
Caffeine
Human Body
Action Potentials
Oxidation-Reduction
Intercellular Signaling Peptides and Proteins
Biomarkers

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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Does tea prevent cancer? Evidence from laboratory and human intervention studies. / Lambert, Joshua D.

In: American Journal of Clinical Nutrition, Vol. 98, No. 6, 01.12.2013, p. 1667S-1675S.

Research output: Contribution to journalArticle

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