Does weight history affect fibrosis in the setting of chronic liver disease?

Research output: Contribution to journalArticle

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Abstract

Aim: To evaluate weight history in chronic liver disease and assess for associations with advanced fibrosis. Weight and Lifestyle Inventory (WALI) was used to assess lifelong weight and eating habits. Results: 38 patients had a diagnosis of nonalcoholic fatty liver disease (NAFLD) and 37 had other chronic liver disease. The body mass index (BMI) did not predict the presence of advanced fibrosis. The time with BMI over 30 kg/m2 was 19.2 years ± 15.7 with advanced fibrosis and 8.6 years ± 10.4 in the non-advanced group (p = 0.002). Independent predictors of fibrosis were: 1) Non-NAFLD (OR 6.2); 2) obesity, with a BMI over 30 for more than 15 years (OR 12.4); 3) at least moderate alcohol use (OR 12.2); 4) advanced age (OR 3.3). Weight history did not impact NALFD differently from Non-NAFLD. Conclusions: BMI over 30 for more than 15 years increases the risk of advanced fibrosis in all chronic liver diseases, on par with the risk of alcohol ingestion.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalJournal of Gastrointestinal and Liver Diseases
Volume18
Issue number3
StatePublished - Dec 1 2009

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Liver Diseases
Fibrosis
Chronic Disease
History
Weights and Measures
Body Mass Index
Fatty Liver
Alcohols
Feeding Behavior
Life Style
Obesity
Eating
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

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title = "Does weight history affect fibrosis in the setting of chronic liver disease?",
abstract = "Aim: To evaluate weight history in chronic liver disease and assess for associations with advanced fibrosis. Weight and Lifestyle Inventory (WALI) was used to assess lifelong weight and eating habits. Results: 38 patients had a diagnosis of nonalcoholic fatty liver disease (NAFLD) and 37 had other chronic liver disease. The body mass index (BMI) did not predict the presence of advanced fibrosis. The time with BMI over 30 kg/m2 was 19.2 years ± 15.7 with advanced fibrosis and 8.6 years ± 10.4 in the non-advanced group (p = 0.002). Independent predictors of fibrosis were: 1) Non-NAFLD (OR 6.2); 2) obesity, with a BMI over 30 for more than 15 years (OR 12.4); 3) at least moderate alcohol use (OR 12.2); 4) advanced age (OR 3.3). Weight history did not impact NALFD differently from Non-NAFLD. Conclusions: BMI over 30 for more than 15 years increases the risk of advanced fibrosis in all chronic liver diseases, on par with the risk of alcohol ingestion.",
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Does weight history affect fibrosis in the setting of chronic liver disease? / Riley, Thomas R.; Taheri, Mohammad; Schreibman, Ian R.

In: Journal of Gastrointestinal and Liver Diseases, Vol. 18, No. 3, 01.12.2009, p. 299-302.

Research output: Contribution to journalArticle

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