Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice

Rachel L. Poole, David A. Connor, Thomas J. Gould

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Withdrawal from chronic nicotine is associated with cognitive deficits. Therapies that ameliorate cognitive deficits during withdrawal aid in preventing relapse during quit attempts. Withdrawal-induced deficits in contextual learning are associated with nicotinic acetylcholine receptor upregulation. The aim of the present study was to determine if the acetylcholinesterase inhibitor donepezil has the ability to reverse nicotine withdrawal-induced deficits in contextual learning. Results demonstrated that low doses of donepezil, which do not enhance contextual learning or alter locomotor activity/anxiety-related behavior, can reverse nicotine withdrawal-induced deficits in contextual learning. Thus, donepezil may have therapeutic value for ameliorating cognitive deficits associated with nicotine withdrawal and for preventing relapse.

Original languageEnglish (US)
Pages (from-to)588-593
Number of pages6
JournalBehavioral Neuroscience
Volume128
Issue number5
DOIs
StatePublished - Jan 1 2014

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Nicotine
Inbred C57BL Mouse
Fear
Learning
Recurrence
Aptitude
Cholinesterase Inhibitors
Nicotinic Receptors
Cognitive Therapy
Locomotion
Up-Regulation
Anxiety
Conditioning (Psychology)
donepezil
Therapeutics

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

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Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice. / Poole, Rachel L.; Connor, David A.; Gould, Thomas J.

In: Behavioral Neuroscience, Vol. 128, No. 5, 01.01.2014, p. 588-593.

Research output: Contribution to journalArticle

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