2 Citations (Scopus)

Abstract

The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported. We reviewed 360 post-kidney transplant recipients (transplant: 2002-2013; follow-up: 5.6. ±. 3.3. years). DQ DSA was detected in 46 of 57 patients who developed DSA. DSA specificity was consistent with donor mismatched DQ trans-heterodimers in three patients: DQ2.5 (DQB1*02, DQA1*05), DQ2.3 (DQB1*02, DQA1*03), and DQ4.3 (DQB1*04, DQA1*03). Two of them eventually lost grafts (2 and 5. years later) with allograft nephropathy. In conclusion, post-transplant patients may develop DSA to donor DQ trans-heterodimers. Further studies are warranted to determine the clinical significance of such DSAs.

Original languageEnglish (US)
Pages (from-to)587-590
Number of pages4
JournalHuman Immunology
Volume76
Issue number8
DOIs
StatePublished - Jan 1 2015

Fingerprint

HLA-DQ Antigens
Tissue Donors
Antibodies
Transplants
Antibody Specificity
Allografts
Kidney

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

@article{576ba9f6d6644ada81100d53dfac6a07,
title = "Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer",
abstract = "The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported. We reviewed 360 post-kidney transplant recipients (transplant: 2002-2013; follow-up: 5.6. ±. 3.3. years). DQ DSA was detected in 46 of 57 patients who developed DSA. DSA specificity was consistent with donor mismatched DQ trans-heterodimers in three patients: DQ2.5 (DQB1*02, DQA1*05), DQ2.3 (DQB1*02, DQA1*03), and DQ4.3 (DQB1*04, DQA1*03). Two of them eventually lost grafts (2 and 5. years later) with allograft nephropathy. In conclusion, post-transplant patients may develop DSA to donor DQ trans-heterodimers. Further studies are warranted to determine the clinical significance of such DSAs.",
author = "Habig, {Dennis F.} and Gaspari, {Justine L.} and Lokhandwala, {Parvez M.} and Ronald Domen and Catherine Abendroth and Zakiyah Kadry and Nasrollah Ghahramani and Shah, {Riaz Ali} and Ashokkumar Jain and Hiroko Shike",
year = "2015",
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doi = "10.1016/j.humimm.2015.09.004",
language = "English (US)",
volume = "76",
pages = "587--590",
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Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer. / Habig, Dennis F.; Gaspari, Justine L.; Lokhandwala, Parvez M.; Domen, Ronald; Abendroth, Catherine; Kadry, Zakiyah; Ghahramani, Nasrollah; Shah, Riaz Ali; Jain, Ashokkumar; Shike, Hiroko.

In: Human Immunology, Vol. 76, No. 8, 01.01.2015, p. 587-590.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Donor-specific antibody to trans-encoded donor HLA-DQ heterodimer

AU - Habig, Dennis F.

AU - Gaspari, Justine L.

AU - Lokhandwala, Parvez M.

AU - Domen, Ronald

AU - Abendroth, Catherine

AU - Kadry, Zakiyah

AU - Ghahramani, Nasrollah

AU - Shah, Riaz Ali

AU - Jain, Ashokkumar

AU - Shike, Hiroko

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported. We reviewed 360 post-kidney transplant recipients (transplant: 2002-2013; follow-up: 5.6. ±. 3.3. years). DQ DSA was detected in 46 of 57 patients who developed DSA. DSA specificity was consistent with donor mismatched DQ trans-heterodimers in three patients: DQ2.5 (DQB1*02, DQA1*05), DQ2.3 (DQB1*02, DQA1*03), and DQ4.3 (DQB1*04, DQA1*03). Two of them eventually lost grafts (2 and 5. years later) with allograft nephropathy. In conclusion, post-transplant patients may develop DSA to donor DQ trans-heterodimers. Further studies are warranted to determine the clinical significance of such DSAs.

AB - The majority of de novo donor specific HLA antibodies (DSAs) in transplant patients are directed to HLA-DQ antigens, which consist of a heterodimer of alpha and beta chains. Although a heterodimer can theoretically be cis- or trans-encoded, the sensitizing forms generally appear to be forms. DSA to DQ trans-heterodimer has never been reported. We reviewed 360 post-kidney transplant recipients (transplant: 2002-2013; follow-up: 5.6. ±. 3.3. years). DQ DSA was detected in 46 of 57 patients who developed DSA. DSA specificity was consistent with donor mismatched DQ trans-heterodimers in three patients: DQ2.5 (DQB1*02, DQA1*05), DQ2.3 (DQB1*02, DQA1*03), and DQ4.3 (DQB1*04, DQA1*03). Two of them eventually lost grafts (2 and 5. years later) with allograft nephropathy. In conclusion, post-transplant patients may develop DSA to donor DQ trans-heterodimers. Further studies are warranted to determine the clinical significance of such DSAs.

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