Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome

B. Aramini, C. Kim, S. Diangelo, E. Petersen, D. J. Lederer, L. Shah, H. Robbins, Joanna Floros, S. M. Arcasoy, J. R. Sonett, F. D'Ovidio

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Chronic lung allograft dysfunction (CLAD) is the major factor limiting long-term success of lung transplantation. Polymorphisms of surfactant protein D (SP-D), an important molecule within lung innate immunity, have been associated with various lung diseases. We investigated the association between donor lung SP-D polymorphisms and posttransplant CLAD and survival in 191 lung transplant recipients consecutively transplanted. Recipients were prospectively followed with routine pulmonary function tests. Donor DNA was assayed by pyrosequencing for SP-D polymorphisms of two single-nucleotide variations altering amino acids in the mature protein N-terminal domain codon 11 (Met11Thr), and in codon 160 (Ala160Thr) of the C-terminal domain. CLAD was diagnosed in 88/191 patients, and 60/191 patients have died. Recipients of allografts that expressed the homozygous Met11Met variant of aa11 had significantly greater freedom from CLAD development and better survival compared to those with the homozygous Thr11Th variant of aa11. No significant association was noted for SP-D variants of aa160. Lung allografts with the SP-D polymorphic variant Thr11Th of aa11 are associated with development of CLAD and reduced survival. The observed genetic differences of the donor lung, potentially with their effects on innate immunity, may influence the clinical outcomes after lung transplantation. This study follows principles of Mendelian randomization to show that polymorphisms of the donor lung innate immunity molecule surfactant protein SP-D predict recipient post - lung transplant development of chronic lung allograft dysfunction and survival.

Original languageEnglish (US)
Pages (from-to)2130-2136
Number of pages7
JournalAmerican Journal of Transplantation
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Pulmonary Surfactant-Associated Protein D
Transplants
Lung
Allografts
Innate Immunity
Tissue Donors
Survival
Lung Transplantation
Codon
Pulmonary Surfactant-Associated Proteins
Respiratory Function Tests
Random Allocation
Surface-Active Agents
Lung Diseases
Single Nucleotide Polymorphism

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Aramini, B., Kim, C., Diangelo, S., Petersen, E., Lederer, D. J., Shah, L., ... D'Ovidio, F. (2013). Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome. American Journal of Transplantation, 13(8), 2130-2136. https://doi.org/10.1111/ajt.12326
Aramini, B. ; Kim, C. ; Diangelo, S. ; Petersen, E. ; Lederer, D. J. ; Shah, L. ; Robbins, H. ; Floros, Joanna ; Arcasoy, S. M. ; Sonett, J. R. ; D'Ovidio, F. / Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome. In: American Journal of Transplantation. 2013 ; Vol. 13, No. 8. pp. 2130-2136.
@article{90691bc651c44fc69181ef031e1f4c45,
title = "Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome",
abstract = "Chronic lung allograft dysfunction (CLAD) is the major factor limiting long-term success of lung transplantation. Polymorphisms of surfactant protein D (SP-D), an important molecule within lung innate immunity, have been associated with various lung diseases. We investigated the association between donor lung SP-D polymorphisms and posttransplant CLAD and survival in 191 lung transplant recipients consecutively transplanted. Recipients were prospectively followed with routine pulmonary function tests. Donor DNA was assayed by pyrosequencing for SP-D polymorphisms of two single-nucleotide variations altering amino acids in the mature protein N-terminal domain codon 11 (Met11Thr), and in codon 160 (Ala160Thr) of the C-terminal domain. CLAD was diagnosed in 88/191 patients, and 60/191 patients have died. Recipients of allografts that expressed the homozygous Met11Met variant of aa11 had significantly greater freedom from CLAD development and better survival compared to those with the homozygous Thr11Th variant of aa11. No significant association was noted for SP-D variants of aa160. Lung allografts with the SP-D polymorphic variant Thr11Th of aa11 are associated with development of CLAD and reduced survival. The observed genetic differences of the donor lung, potentially with their effects on innate immunity, may influence the clinical outcomes after lung transplantation. This study follows principles of Mendelian randomization to show that polymorphisms of the donor lung innate immunity molecule surfactant protein SP-D predict recipient post - lung transplant development of chronic lung allograft dysfunction and survival.",
author = "B. Aramini and C. Kim and S. Diangelo and E. Petersen and Lederer, {D. J.} and L. Shah and H. Robbins and Joanna Floros and Arcasoy, {S. M.} and Sonett, {J. R.} and F. D'Ovidio",
year = "2013",
month = "8",
day = "1",
doi = "10.1111/ajt.12326",
language = "English (US)",
volume = "13",
pages = "2130--2136",
journal = "American Journal of Transplantation",
issn = "1600-6135",
publisher = "Wiley-Blackwell",
number = "8",

}

Aramini, B, Kim, C, Diangelo, S, Petersen, E, Lederer, DJ, Shah, L, Robbins, H, Floros, J, Arcasoy, SM, Sonett, JR & D'Ovidio, F 2013, 'Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome', American Journal of Transplantation, vol. 13, no. 8, pp. 2130-2136. https://doi.org/10.1111/ajt.12326

Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome. / Aramini, B.; Kim, C.; Diangelo, S.; Petersen, E.; Lederer, D. J.; Shah, L.; Robbins, H.; Floros, Joanna; Arcasoy, S. M.; Sonett, J. R.; D'Ovidio, F.

In: American Journal of Transplantation, Vol. 13, No. 8, 01.08.2013, p. 2130-2136.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Donor surfactant protein D (SP-D) polymorphisms are associated with lung transplant outcome

AU - Aramini, B.

AU - Kim, C.

AU - Diangelo, S.

AU - Petersen, E.

AU - Lederer, D. J.

AU - Shah, L.

AU - Robbins, H.

AU - Floros, Joanna

AU - Arcasoy, S. M.

AU - Sonett, J. R.

AU - D'Ovidio, F.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Chronic lung allograft dysfunction (CLAD) is the major factor limiting long-term success of lung transplantation. Polymorphisms of surfactant protein D (SP-D), an important molecule within lung innate immunity, have been associated with various lung diseases. We investigated the association between donor lung SP-D polymorphisms and posttransplant CLAD and survival in 191 lung transplant recipients consecutively transplanted. Recipients were prospectively followed with routine pulmonary function tests. Donor DNA was assayed by pyrosequencing for SP-D polymorphisms of two single-nucleotide variations altering amino acids in the mature protein N-terminal domain codon 11 (Met11Thr), and in codon 160 (Ala160Thr) of the C-terminal domain. CLAD was diagnosed in 88/191 patients, and 60/191 patients have died. Recipients of allografts that expressed the homozygous Met11Met variant of aa11 had significantly greater freedom from CLAD development and better survival compared to those with the homozygous Thr11Th variant of aa11. No significant association was noted for SP-D variants of aa160. Lung allografts with the SP-D polymorphic variant Thr11Th of aa11 are associated with development of CLAD and reduced survival. The observed genetic differences of the donor lung, potentially with their effects on innate immunity, may influence the clinical outcomes after lung transplantation. This study follows principles of Mendelian randomization to show that polymorphisms of the donor lung innate immunity molecule surfactant protein SP-D predict recipient post - lung transplant development of chronic lung allograft dysfunction and survival.

AB - Chronic lung allograft dysfunction (CLAD) is the major factor limiting long-term success of lung transplantation. Polymorphisms of surfactant protein D (SP-D), an important molecule within lung innate immunity, have been associated with various lung diseases. We investigated the association between donor lung SP-D polymorphisms and posttransplant CLAD and survival in 191 lung transplant recipients consecutively transplanted. Recipients were prospectively followed with routine pulmonary function tests. Donor DNA was assayed by pyrosequencing for SP-D polymorphisms of two single-nucleotide variations altering amino acids in the mature protein N-terminal domain codon 11 (Met11Thr), and in codon 160 (Ala160Thr) of the C-terminal domain. CLAD was diagnosed in 88/191 patients, and 60/191 patients have died. Recipients of allografts that expressed the homozygous Met11Met variant of aa11 had significantly greater freedom from CLAD development and better survival compared to those with the homozygous Thr11Th variant of aa11. No significant association was noted for SP-D variants of aa160. Lung allografts with the SP-D polymorphic variant Thr11Th of aa11 are associated with development of CLAD and reduced survival. The observed genetic differences of the donor lung, potentially with their effects on innate immunity, may influence the clinical outcomes after lung transplantation. This study follows principles of Mendelian randomization to show that polymorphisms of the donor lung innate immunity molecule surfactant protein SP-D predict recipient post - lung transplant development of chronic lung allograft dysfunction and survival.

UR - http://www.scopus.com/inward/record.url?scp=84881378308&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881378308&partnerID=8YFLogxK

U2 - 10.1111/ajt.12326

DO - 10.1111/ajt.12326

M3 - Article

C2 - 23841811

AN - SCOPUS:84881378308

VL - 13

SP - 2130

EP - 2136

JO - American Journal of Transplantation

JF - American Journal of Transplantation

SN - 1600-6135

IS - 8

ER -