Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection

Eun Joo Park, Jeffery Dodds, Nadine Barrie Smith

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Prior studies have demonstrated the effectiveness of noninvasive transdermal insulin delivery using a cymbal transducer array. In this study the physiologic response to ultrasound mediated transdermal insulin delivery is compared to that of subcutaneously administered insulin. Anesthetized rats (350-550 g) were divided into four groups of four animals; one group representing ultrasound mediated insulin delivery and three representing subcutaneously administered insulin (0.15, 0.20, and 0.25 U/kg). The cymbal array was operated for 60 minutes at 20 kHz with 100 mW/cm2 spatial-peak temporal-peak intensity and a 20% duty cycle. The blood glucose level was determined at the beginning of the experiment and, following insulin administration, every 15 minutes for 90 minutes for both the ultrasound and injection groups. The change in blood glucose from baseline was compared between groups. When administered by subcutaneous injection at insulin doses of 0.15 and 0.20 U/kg, there was little change in the blood glucose levels over the 90 minute experiment. Following subcutaneous administration of insulin at a dose of 0.25 U/kg, blood glucose decreased by 190±96mg/dl (mean±SD) at 90 minutes. The change in blood glucose following ultrasound mediated insulin delivery was -262±40mg/dl at 90 minutes. As expected, the magnitude of change in blood glucose between the three injection groups was dependant on the dose of insulin administered. The change in blood glucose in the ultrasound group was greater than that observed in the injection groups suggesting that a higher effective dose of insulin was delivered.

Original languageEnglish (US)
Title of host publication9th International Symposium on Therapeutic Ultrasound - ISTU 2009
Pages307-310
Number of pages4
DOIs
StatePublished - Mar 30 2010
Event9th International Symposium on Therapeutic Ultrasound, ISTU 2009 - Aix-en-Provence, France
Duration: Sep 24 2009Sep 26 2009

Publication series

NameAIP Conference Proceedings
Volume1215
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other9th International Symposium on Therapeutic Ultrasound, ISTU 2009
CountryFrance
CityAix-en-Provence
Period9/24/099/26/09

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)

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  • Cite this

    Park, E. J., Dodds, J., & Barrie Smith, N. (2010). Dose comparison of ultrasonic transdermal insulin delivery to subcutaneous insulin injection. In 9th International Symposium on Therapeutic Ultrasound - ISTU 2009 (pp. 307-310). (AIP Conference Proceedings; Vol. 1215). https://doi.org/10.1063/1.3367167