TY - JOUR
T1 - Dose-dependent effects of aerobic exercise on clinically relevant biomarkers among healthy women at high genetic risk for breast cancer
T2 - A secondary analysis of a randomized controlled study
AU - Ehret, Christopher J.
AU - Zhou, Shouhao
AU - Tchou, Julia C.
AU - Schmitz, Kathryn H.
AU - Sturgeon, Kathleen M.
N1 - Funding Information:
The authors thank Dr. Heather Collins and the University of Pennsylvania Diabetes Research Center (DRC) for the use of the RIA Biomarkers Core (P30-DK19525). This work was supported by the National Center for Advancing Translational Sciences (UL1 TR002014, UL1 TR000003, and KL2 TR002015); and the National Cancer Institute at the National Institutes of Health (R01 CA131333).
Funding Information:
The authors thank Dr. Heather Collins and the University of Pennsylvania Diabetes Research Center (DRC) for the use of the RIA Biomarkers Core (P30‐DK19525). This work was supported by the National Center for Advancing Translational Sciences (UL1 TR002014, UL1 TR000003, and KL2 TR002015); and the National Cancer Institute at the National Institutes of Health (R01 CA131333).
Publisher Copyright:
© 2021 The Authors. Cancer Reports published by Wiley Periodicals LLC.
PY - 2022/5
Y1 - 2022/5
N2 - Background: Excess adiposity and dysregulated metabolism are associated with increased cancer risk. Triglycerides, cholesterol, glucose, insulin, HOMA-IR, and VO2max are robust clinical-metabolic biomarkers of overall health. Aims: Aerobic exercise may improve clinical-metabolic biomarkers and decrease cancer risk. This secondary analysis of the WISER Sister randomized controlled trial investigated dose-dependent effects of aerobic exercise on clinical biomarker levels in women at high genetic risk for breast cancer. Methods and Results: One hundred thirty-nine participants were randomized to: control (<75 min/week), low-dose (150 min/week), and high-dose (300 min/week) aerobic exercise intervention groups. Intervention adherence was assessed via heart monitor. Fasting blood draws, cardio-pulmonary tests, and demographical surveys were taken at baseline and 5 months. Triglyceride, cholesterol, glucose, insulin, and VO2max changes were assessed for 80 of the 122 study completers. Ninety-six percent of assayed-completers adhered to >80% of their exercise dose. A significant dose-dependent increase in VO2max was observed for the low-dose and high-dose groups compared to control. No intervention effects were observed for plasma biomarkers. Overweight women (BMI > 25) showed a significant decrease in insulin levels and a trend for decreased triglycerides following exercise intervention. Significant increases in VO2max were independent of BMI stratification. Conclusion: Women at high genetic risk for breast cancer should maintain healthy weights and aerobic capacities through aerobic exercise to achieve measurable benefits on overall health. For overweight women, exercise appears to improve subclinical metabolic dysregulation. However, normal weight women were unaffected by aerobic exercise as their biomarker levels may be below the threshold for improvement. VO2max increases solely quantified the benefits of exercise in already healthy women at high-risk for breast cancer.
AB - Background: Excess adiposity and dysregulated metabolism are associated with increased cancer risk. Triglycerides, cholesterol, glucose, insulin, HOMA-IR, and VO2max are robust clinical-metabolic biomarkers of overall health. Aims: Aerobic exercise may improve clinical-metabolic biomarkers and decrease cancer risk. This secondary analysis of the WISER Sister randomized controlled trial investigated dose-dependent effects of aerobic exercise on clinical biomarker levels in women at high genetic risk for breast cancer. Methods and Results: One hundred thirty-nine participants were randomized to: control (<75 min/week), low-dose (150 min/week), and high-dose (300 min/week) aerobic exercise intervention groups. Intervention adherence was assessed via heart monitor. Fasting blood draws, cardio-pulmonary tests, and demographical surveys were taken at baseline and 5 months. Triglyceride, cholesterol, glucose, insulin, and VO2max changes were assessed for 80 of the 122 study completers. Ninety-six percent of assayed-completers adhered to >80% of their exercise dose. A significant dose-dependent increase in VO2max was observed for the low-dose and high-dose groups compared to control. No intervention effects were observed for plasma biomarkers. Overweight women (BMI > 25) showed a significant decrease in insulin levels and a trend for decreased triglycerides following exercise intervention. Significant increases in VO2max were independent of BMI stratification. Conclusion: Women at high genetic risk for breast cancer should maintain healthy weights and aerobic capacities through aerobic exercise to achieve measurable benefits on overall health. For overweight women, exercise appears to improve subclinical metabolic dysregulation. However, normal weight women were unaffected by aerobic exercise as their biomarker levels may be below the threshold for improvement. VO2max increases solely quantified the benefits of exercise in already healthy women at high-risk for breast cancer.
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U2 - 10.1002/cnr2.1497
DO - 10.1002/cnr2.1497
M3 - Article
C2 - 34240819
AN - SCOPUS:85109386469
VL - 5
JO - Cancer Reports
JF - Cancer Reports
SN - 2573-8348
IS - 5
M1 - e1497
ER -
