Dose-effect functions for cocaine self-administration: Effects of schedule and dosing procedure

Glen M. Sizemore, Teresa M. Gaspard, Susy A. Kim, Lois E. Walker, Sheila L. Vrana, Steven I. Dworkin

Research output: Contribution to journalArticle

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Abstract

Research related to determining how procedural variables can alter dose-effect functions for cocaine self-administration is limited. Toward clarifying the role of procedural variables, responding was maintained in rats under either variable-interval (VI) or fixed-ratio (FR) schedules of cocaine infusion. In addition to free-operant FR schedules, discrete-trial FR schedules were evaluated. The dose-effect functions were obtained by either substituting a dose for the usual daily dose, instituting a particular dose for several sessions, or making all doses available within a session. Dose-effect functions for response rate (or number of trials with infusions for the discrete-trial FR) were bitonic for the VI and discrete-trial FR schedules but tended to be strictly decreasing for the free-operant FR schedules. Responding was maintained under FR schedules by a low dose (0.083 mg/infusion) if the dose was substituted for a higher daily dose but not when made available daily. Rate of response was higher under ratio schedules at 0.17 mg/infusion when this dose occurred within the context of other higher doses within a session than when the dose was simply substituted for a higher daily dose. These data indicate that procedural variables can alter dose-response curves for cocaine self-administration.

LanguageEnglish (US)
Pages523-531
Number of pages9
JournalPharmacology Biochemistry and Behavior
Volume57
Issue number3
DOIs
StatePublished - Jul 1 1997

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Self Administration
Cocaine
Appointments and Schedules
Rats
Research

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Cite this

Sizemore, Glen M. ; Gaspard, Teresa M. ; Kim, Susy A. ; Walker, Lois E. ; Vrana, Sheila L. ; Dworkin, Steven I./ Dose-effect functions for cocaine self-administration : Effects of schedule and dosing procedure. In: Pharmacology Biochemistry and Behavior. 1997 ; Vol. 57, No. 3. pp. 523-531
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Dose-effect functions for cocaine self-administration : Effects of schedule and dosing procedure. / Sizemore, Glen M.; Gaspard, Teresa M.; Kim, Susy A.; Walker, Lois E.; Vrana, Sheila L.; Dworkin, Steven I.

In: Pharmacology Biochemistry and Behavior, Vol. 57, No. 3, 01.07.1997, p. 523-531.

Research output: Contribution to journalArticle

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