Dose-response effects of aerobic exercise on body composition among colon cancer survivors: A randomised controlled trial

Justin C. Brown, Babette S. Zemel, Andrea B. Troxel, Michael R. Rickels, Nevena Damjanov, Bonnie Ky, Andrew D. Rhim, Anil K. Rustgi, Kerry S. Courneya, Kathryn H. Schmitz

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11 Citations (Scopus)

Abstract

Background:Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue.Methods:Thirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care control, 150 min wk-1 of aerobic exercise (low dose) and 300 min wk-1 of aerobic exercise (high dose) for 6 months. The prespecified key body composition outcome was visceral adipose tissue quantified using dual energy X-ray absorptiometry.Results:Exercise reduced visceral adipose tissue in dose-response fashion (P trend =0.008). Compared with the control group, the low-and high-dose exercise groups lost 9.5 cm 2 (95% CI:-22.4, 3.5) and 13.6 cm 2 (95% CI:-27.0,-0.1) in visceral adipose tissue, respectively. Each 60 min wk-1 increase in exercise predicted a 2.7 cm 2 (95% CI:-5.4,-0.1) reduction in visceral adipose tissue.Conclusions:Aerobic exercise reduces visceral adipose tissue in dose-response fashion among patients with stage I-III colon cancer. Visceral adipose tissue may be a mechanism through which exercise reduces the risk of disease recurrence among colon cancer survivors.

Original languageEnglish (US)
Pages (from-to)1614-1620
Number of pages7
JournalBritish Journal of Cancer
Volume117
Issue number11
DOIs
StatePublished - Nov 21 2017

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Intra-Abdominal Fat
Body Composition
Colonic Neoplasms
Survivors
Randomized Controlled Trials
Exercise
Recurrence
Photon Absorptiometry
Control Groups

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Brown, Justin C. ; Zemel, Babette S. ; Troxel, Andrea B. ; Rickels, Michael R. ; Damjanov, Nevena ; Ky, Bonnie ; Rhim, Andrew D. ; Rustgi, Anil K. ; Courneya, Kerry S. ; Schmitz, Kathryn H. / Dose-response effects of aerobic exercise on body composition among colon cancer survivors : A randomised controlled trial. In: British Journal of Cancer. 2017 ; Vol. 117, No. 11. pp. 1614-1620.
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abstract = "Background:Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue.Methods:Thirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care control, 150 min wk-1 of aerobic exercise (low dose) and 300 min wk-1 of aerobic exercise (high dose) for 6 months. The prespecified key body composition outcome was visceral adipose tissue quantified using dual energy X-ray absorptiometry.Results:Exercise reduced visceral adipose tissue in dose-response fashion (P trend =0.008). Compared with the control group, the low-and high-dose exercise groups lost 9.5 cm 2 (95{\%} CI:-22.4, 3.5) and 13.6 cm 2 (95{\%} CI:-27.0,-0.1) in visceral adipose tissue, respectively. Each 60 min wk-1 increase in exercise predicted a 2.7 cm 2 (95{\%} CI:-5.4,-0.1) reduction in visceral adipose tissue.Conclusions:Aerobic exercise reduces visceral adipose tissue in dose-response fashion among patients with stage I-III colon cancer. Visceral adipose tissue may be a mechanism through which exercise reduces the risk of disease recurrence among colon cancer survivors.",
author = "Brown, {Justin C.} and Zemel, {Babette S.} and Troxel, {Andrea B.} and Rickels, {Michael R.} and Nevena Damjanov and Bonnie Ky and Rhim, {Andrew D.} and Rustgi, {Anil K.} and Courneya, {Kerry S.} and Schmitz, {Kathryn H.}",
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Brown, JC, Zemel, BS, Troxel, AB, Rickels, MR, Damjanov, N, Ky, B, Rhim, AD, Rustgi, AK, Courneya, KS & Schmitz, KH 2017, 'Dose-response effects of aerobic exercise on body composition among colon cancer survivors: A randomised controlled trial', British Journal of Cancer, vol. 117, no. 11, pp. 1614-1620. https://doi.org/10.1038/bjc.2017.339

Dose-response effects of aerobic exercise on body composition among colon cancer survivors : A randomised controlled trial. / Brown, Justin C.; Zemel, Babette S.; Troxel, Andrea B.; Rickels, Michael R.; Damjanov, Nevena; Ky, Bonnie; Rhim, Andrew D.; Rustgi, Anil K.; Courneya, Kerry S.; Schmitz, Kathryn H.

In: British Journal of Cancer, Vol. 117, No. 11, 21.11.2017, p. 1614-1620.

Research output: Contribution to journalArticle

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T1 - Dose-response effects of aerobic exercise on body composition among colon cancer survivors

T2 - A randomised controlled trial

AU - Brown, Justin C.

AU - Zemel, Babette S.

AU - Troxel, Andrea B.

AU - Rickels, Michael R.

AU - Damjanov, Nevena

AU - Ky, Bonnie

AU - Rhim, Andrew D.

AU - Rustgi, Anil K.

AU - Courneya, Kerry S.

AU - Schmitz, Kathryn H.

PY - 2017/11/21

Y1 - 2017/11/21

N2 - Background:Physical activity is associated with a lower risk of disease recurrence among colon cancer survivors. Excess visceral adipose tissue is associated with a higher risk of disease recurrence among colon cancer survivors. The pathways through which physical activity may alter disease outcomes are unknown, but may be mediated by changes in visceral adipose tissue.Methods:Thirty-nine stage I-III colon cancer survivors were randomised to one of three groups: usual-care control, 150 min wk-1 of aerobic exercise (low dose) and 300 min wk-1 of aerobic exercise (high dose) for 6 months. The prespecified key body composition outcome was visceral adipose tissue quantified using dual energy X-ray absorptiometry.Results:Exercise reduced visceral adipose tissue in dose-response fashion (P trend =0.008). Compared with the control group, the low-and high-dose exercise groups lost 9.5 cm 2 (95% CI:-22.4, 3.5) and 13.6 cm 2 (95% CI:-27.0,-0.1) in visceral adipose tissue, respectively. Each 60 min wk-1 increase in exercise predicted a 2.7 cm 2 (95% CI:-5.4,-0.1) reduction in visceral adipose tissue.Conclusions:Aerobic exercise reduces visceral adipose tissue in dose-response fashion among patients with stage I-III colon cancer. Visceral adipose tissue may be a mechanism through which exercise reduces the risk of disease recurrence among colon cancer survivors.

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