Double-stranded DNA breaks and gene functions in recombination and meiosis

Wuxing Li, Hong Ma

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Meiotic prophase I is a long and complex phase. Homologous recombination is an important process that occurs between homologous chromosomes during meiotic prophase I. Formation of chiasmata, which hold homologous chromosomes together until the metaphase I to anaphase I transition, is critical for proper chromosome segregation. Recent studies have suggested that the SPO11 proteins have conserved functions in a number of organisms in generating sites of double-stranded DNA breaks (DSBs) that are thought to be the starting points of homologous recombination. Processing of these sites of DSBs requires the function of RecA homologs, such as RAD51, DMC1, and others, as suggested by mutant studies; thus the failure to repair these meiotic DSBs results in abnormal chromosomal alternations, leading to disrupted meiosis. Recent discoveries on the functions of these RecA homologs have improved the understanding of the mechanisms underlying meiotic homologous recombination.

Original languageEnglish (US)
Pages (from-to)402-412
Number of pages11
JournalCell Research
Volume16
Issue number5
DOIs
StatePublished - May 2006

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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