Downstaging colorectal liver metastases by concomitant unilateral portal vein ligation and selective intra-arterial chemotherapy

N. Selzner, B. C. Pestalozzi, Z. Kadry, M. Selzner, S. Wildermuth, P. A. Clavien

Research output: Contribution to journalArticle

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Abstract

Background: Although selective intrahepatic arterial chemotherapy successfully downstaged irresectable colorectal liver metastases in a previous study, curative resection was rarely possible, as the remnant healthy liver volume was inadequate. This pilot study evaluated the efficacy of concomitant unilateral portal vein ligation and selective intrahepatic arterial chemotherapy in downstaging such tumours. Methods: The study included 11 patients with irresectable colorectal liver metastases. Selective intrahepatic arterial chemotherapy was delivered using a subcutaneous pump, and each patient underwent concomitant unilateral portal vein ligation of the hemiliver judged to have the higher tumour load. Chemotherapy involved serial administration of floxuridine for 2 weeks every 4 weeks. Results: All patients developed significant atrophy of the hemiliver subjected to portal vein ligation and contralateral hypertrophy. There was no increase in tumour load within 6 months of therapy, and the load decreased by 60 per cent in the hemiliver ipsilateral to the ligated vein. At 3 months, six of 11 patients showed a significant response to chemotherapy. In four patients, downstaging allowed curative resection after only three cycles of chemotherapy. These patients survived at least 20 months afterwards. Conclusion: Combined unilateral portal vein ligation and selective intrahepatic arterial chemotherapy produced substantial atrophy of the ipsilateral hemiliver along with contralateral hypertrophy, without increased tumour growth in the regenerating hemiliver.

Original languageEnglish (US)
Pages (from-to)587-592
Number of pages6
JournalBritish Journal of Surgery
Volume93
Issue number5
DOIs
StatePublished - May 1 2006

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Portal Vein
Ligation
Neoplasm Metastasis
Drug Therapy
Liver
Tumor Burden
Hypertrophy
Atrophy
Floxuridine
Veins
Neoplasms
Growth

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Selzner, N. ; Pestalozzi, B. C. ; Kadry, Z. ; Selzner, M. ; Wildermuth, S. ; Clavien, P. A. / Downstaging colorectal liver metastases by concomitant unilateral portal vein ligation and selective intra-arterial chemotherapy. In: British Journal of Surgery. 2006 ; Vol. 93, No. 5. pp. 587-592.
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abstract = "Background: Although selective intrahepatic arterial chemotherapy successfully downstaged irresectable colorectal liver metastases in a previous study, curative resection was rarely possible, as the remnant healthy liver volume was inadequate. This pilot study evaluated the efficacy of concomitant unilateral portal vein ligation and selective intrahepatic arterial chemotherapy in downstaging such tumours. Methods: The study included 11 patients with irresectable colorectal liver metastases. Selective intrahepatic arterial chemotherapy was delivered using a subcutaneous pump, and each patient underwent concomitant unilateral portal vein ligation of the hemiliver judged to have the higher tumour load. Chemotherapy involved serial administration of floxuridine for 2 weeks every 4 weeks. Results: All patients developed significant atrophy of the hemiliver subjected to portal vein ligation and contralateral hypertrophy. There was no increase in tumour load within 6 months of therapy, and the load decreased by 60 per cent in the hemiliver ipsilateral to the ligated vein. At 3 months, six of 11 patients showed a significant response to chemotherapy. In four patients, downstaging allowed curative resection after only three cycles of chemotherapy. These patients survived at least 20 months afterwards. Conclusion: Combined unilateral portal vein ligation and selective intrahepatic arterial chemotherapy produced substantial atrophy of the ipsilateral hemiliver along with contralateral hypertrophy, without increased tumour growth in the regenerating hemiliver.",
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Downstaging colorectal liver metastases by concomitant unilateral portal vein ligation and selective intra-arterial chemotherapy. / Selzner, N.; Pestalozzi, B. C.; Kadry, Z.; Selzner, M.; Wildermuth, S.; Clavien, P. A.

In: British Journal of Surgery, Vol. 93, No. 5, 01.05.2006, p. 587-592.

Research output: Contribution to journalArticle

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AU - Selzner, N.

AU - Pestalozzi, B. C.

AU - Kadry, Z.

AU - Selzner, M.

AU - Wildermuth, S.

AU - Clavien, P. A.

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