Downstaging des métastases hépatiques d'origine colorectale et des carcinomes hépatocellulaires par chimiothérapie sélective intra-artérielle hépatique

Translated title of the contribution: Downstaging of hepatocellular carcinoma and liver metastases from colorectal cancer by selective intra arterial chemotherapy

Nazia Selzner, Zakiyah Kadry, Jean Marie Michel, Pierre Alain Clavien

Research output: Contribution to journalArticle

Abstract

While resection is the sole chance of cure in patients with hepatocellular carcinoma or metastatic colorectal cancer to the liver, many patients are not candidates for surgery at the time of diagnosis. Strategies aiming at downstaging large or multi-focal tumors to enable curative resection are appealing. Neoadjuvant hepatic intra-arterial chemotherapy is a safe and well tolerated technique. We studied its effects in patients with unresectable hepatocellular carcinoma or metastatic colorectal cancer to the liver in the absence of extra-hepatic disease. Our results demonstrated successful downstaging of initial tumors followed by curative resection. The success of this strategy however requires a multidisciplinary approach in a hepato-biliary center with extensive experience in the management of these patients.

Original languageFrench
Pages (from-to)989-991
Number of pages3
JournalMedecine et Hygiene
Volume60
Issue number2392
StatePublished - May 15 2002

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Hepatocellular Carcinoma
Colorectal Neoplasms
Neoplasm Metastasis
Drug Therapy
Liver
Liver Neoplasms
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Downstaging des m{\'e}tastases h{\'e}patiques d'origine colorectale et des carcinomes h{\'e}patocellulaires par chimioth{\'e}rapie s{\'e}lective intra-art{\'e}rielle h{\'e}patique",
abstract = "While resection is the sole chance of cure in patients with hepatocellular carcinoma or metastatic colorectal cancer to the liver, many patients are not candidates for surgery at the time of diagnosis. Strategies aiming at downstaging large or multi-focal tumors to enable curative resection are appealing. Neoadjuvant hepatic intra-arterial chemotherapy is a safe and well tolerated technique. We studied its effects in patients with unresectable hepatocellular carcinoma or metastatic colorectal cancer to the liver in the absence of extra-hepatic disease. Our results demonstrated successful downstaging of initial tumors followed by curative resection. The success of this strategy however requires a multidisciplinary approach in a hepato-biliary center with extensive experience in the management of these patients.",
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Downstaging des métastases hépatiques d'origine colorectale et des carcinomes hépatocellulaires par chimiothérapie sélective intra-artérielle hépatique. / Selzner, Nazia; Kadry, Zakiyah; Michel, Jean Marie; Clavien, Pierre Alain.

In: Medecine et Hygiene, Vol. 60, No. 2392, 15.05.2002, p. 989-991.

Research output: Contribution to journalArticle

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AU - Selzner, Nazia

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AU - Michel, Jean Marie

AU - Clavien, Pierre Alain

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AB - While resection is the sole chance of cure in patients with hepatocellular carcinoma or metastatic colorectal cancer to the liver, many patients are not candidates for surgery at the time of diagnosis. Strategies aiming at downstaging large or multi-focal tumors to enable curative resection are appealing. Neoadjuvant hepatic intra-arterial chemotherapy is a safe and well tolerated technique. We studied its effects in patients with unresectable hepatocellular carcinoma or metastatic colorectal cancer to the liver in the absence of extra-hepatic disease. Our results demonstrated successful downstaging of initial tumors followed by curative resection. The success of this strategy however requires a multidisciplinary approach in a hepato-biliary center with extensive experience in the management of these patients.

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