Dragmacidin E synthesis studies. Preparation of a model cycloheptannelated indole fragment

Ken S. Feldman, Paiboon Ngernmeesri

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

(Chemical Equation Presented) The conversion of N-2,2-dichloropropionyl indole methyl ester into a tetracyclic cycloheptannelated indole model compound for the synthesis of dragmacidin E was accomplished in 10 steps. Key reactions include a Witkop cyclization to fashion a C-C bond at C(4) of the indole nucleus and a subsequent Dieckmann cyclization to deliver the desired cycloheptanoid ring.

Original languageEnglish (US)
Pages (from-to)5449-5452
Number of pages4
JournalOrganic Letters
Volume7
Issue number24
DOIs
StatePublished - Nov 24 2005

All Science Journal Classification (ASJC) codes

  • Molecular Medicine

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