DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety

Koraly Pérez-Edgar, Jillian E. Hardee, Amanda E. Guyer, Brenda E. Benson, Eric E. Nelson, Elena Gorodetsky, David Goldman, Nathan A. Fox, Daniel S. Pine, Monique Ernst

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Behavioral inhibition (BI), a temperament characterized by vigilance to novelty, sensitivity to approach-withdrawal cues and social reticence in childhood, is associated with risk for anxiety in adolescence. Independent studies link reward hyper-responsivity to BI, adolescent anxiety and dopamine gene variants. This exploratory study extends these observations by examining the impact of DRD4 genotype and reward hyper-responsivity on the BI-anxiety link. Adolescents (N = 78) completed a monetary incentive delay task in the fMRI environment. Participants were characterized based on a continuous score of BI and the 7-repeat allele (7R+) of the DRD4 functional polymorphism. Parent-report and self-report measures of anxiety were also collected. Across the entire sample, striatal activation increased systematically with increases in the magnitude of anticipated monetary gains and losses. DRD4 status moderated the relation between BI and activation in the caudate nucleus. Childhood BI was associated with parent report of adolescent anxiety among 7R+ participants with elevated levels of striatal response to incentive cues. DRD4 genotype influenced the relations among neural response to incentives, early childhood BI and anxiety. The findings help refine our understanding of the role reward-related brain systems play in the emergence of anxiety in temperamentally at-risk individuals, building a foundation for future larger scale studies.

Original languageEnglish (US)
Article numbernst001
Pages (from-to)445-453
Number of pages9
JournalSocial cognitive and affective neuroscience
Volume9
Issue number4
DOIs
StatePublished - Apr 2014

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Corpus Striatum
Anxiety
Reward
Motivation
Cues
Genotype
Temperament
Caudate Nucleus
Inhibition (Psychology)
Self Report
Dopamine
Alleles
Magnetic Resonance Imaging
Brain

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Pérez-Edgar, Koraly ; Hardee, Jillian E. ; Guyer, Amanda E. ; Benson, Brenda E. ; Nelson, Eric E. ; Gorodetsky, Elena ; Goldman, David ; Fox, Nathan A. ; Pine, Daniel S. ; Ernst, Monique. / DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety. In: Social cognitive and affective neuroscience. 2014 ; Vol. 9, No. 4. pp. 445-453.
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Pérez-Edgar, K, Hardee, JE, Guyer, AE, Benson, BE, Nelson, EE, Gorodetsky, E, Goldman, D, Fox, NA, Pine, DS & Ernst, M 2014, 'DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety', Social cognitive and affective neuroscience, vol. 9, no. 4, nst001, pp. 445-453. https://doi.org/10.1093/scan/nst001

DRD4 and striatal modulation of the link between childhood behavioral inhibition and adolescent anxiety. / Pérez-Edgar, Koraly; Hardee, Jillian E.; Guyer, Amanda E.; Benson, Brenda E.; Nelson, Eric E.; Gorodetsky, Elena; Goldman, David; Fox, Nathan A.; Pine, Daniel S.; Ernst, Monique.

In: Social cognitive and affective neuroscience, Vol. 9, No. 4, nst001, 04.2014, p. 445-453.

Research output: Contribution to journalArticle

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