Drinking a lot is good for dendritic cells

Research output: Contribution to journalReview article

107 Citations (Scopus)

Abstract

Macropinocytosis is the actin-dependent formation of large vesicles, which allow the internalization of large quantities of fluid-phase solute. In the majority of cells examined, an exogenous stimulus is required to induce the initiation of this endocyticq4 pathway. However, dendritic cells are thought to constitutively macropinocytose large quantities of exogenous solute as part of their sentinel function. In this review we discuss the evidence that dendritic cells macropinocytose exogenous solute and subsequently present antigenic peptides derived from internalized material to T cells. In addition, we put these data into the context of immune surveillance in vivo.

Original languageEnglish (US)
Pages (from-to)443-451
Number of pages9
JournalImmunology
Volume117
Issue number4
DOIs
StatePublished - Apr 1 2006

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Dendritic Cells
Drinking
Actins
T-Lymphocytes
Peptides
cyhalothrin

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Norbury, Christopher. / Drinking a lot is good for dendritic cells. In: Immunology. 2006 ; Vol. 117, No. 4. pp. 443-451.
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Drinking a lot is good for dendritic cells. / Norbury, Christopher.

In: Immunology, Vol. 117, No. 4, 01.04.2006, p. 443-451.

Research output: Contribution to journalReview article

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AU - Norbury, Christopher

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AB - Macropinocytosis is the actin-dependent formation of large vesicles, which allow the internalization of large quantities of fluid-phase solute. In the majority of cells examined, an exogenous stimulus is required to induce the initiation of this endocyticq4 pathway. However, dendritic cells are thought to constitutively macropinocytose large quantities of exogenous solute as part of their sentinel function. In this review we discuss the evidence that dendritic cells macropinocytose exogenous solute and subsequently present antigenic peptides derived from internalized material to T cells. In addition, we put these data into the context of immune surveillance in vivo.

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