Drinking by rats after irritative lesions in the hypothalamus

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The deposition of metallic ions in or near the lateral hypothalamus with a stainless-steel anode causes primary polydipsia lasting about six hours. During this time rats are hyperactive and drink as much as two to three times their normal daily intake. This irritative effect accounts for the polydipsia which sometimes follows lesions in the median eminence of the tuber cinereum of nephrectomized rats. Non-irritative lesions there do not cause primary polydipsia. After six hours rats with chronic diabetes insipidus produced by lesions in the median eminence do not show any effects of irritative lesions on water intake. In addition, when their urine output is suppressed these diabetic rats drink almost exactly the amount of water needed to dilute a cellular thirst stimulus (hypertonic saline) to isotonicity and drink the same amount as controls after equivalent extracellular thirst stimuli (polyethylene glycol) suggesting that important drinking mechanisms are not located in the median eminence.

Original languageEnglish (US)
JournalPhysiology and Behavior
Volume5
Issue number12
DOIs
StatePublished - Jan 1 1970

Fingerprint

Median Eminence
Hypothalamus
Drinking
Psychogenic Polydipsia
Thirst
Tuber Cinereum
Lateral Hypothalamic Area
Polydipsia
Diabetes Insipidus
Stainless Steel
Electrodes
Urine
Ions
Water

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

@article{9d966b452f0c416592915a57b2856aca,
title = "Drinking by rats after irritative lesions in the hypothalamus",
abstract = "The deposition of metallic ions in or near the lateral hypothalamus with a stainless-steel anode causes primary polydipsia lasting about six hours. During this time rats are hyperactive and drink as much as two to three times their normal daily intake. This irritative effect accounts for the polydipsia which sometimes follows lesions in the median eminence of the tuber cinereum of nephrectomized rats. Non-irritative lesions there do not cause primary polydipsia. After six hours rats with chronic diabetes insipidus produced by lesions in the median eminence do not show any effects of irritative lesions on water intake. In addition, when their urine output is suppressed these diabetic rats drink almost exactly the amount of water needed to dilute a cellular thirst stimulus (hypertonic saline) to isotonicity and drink the same amount as controls after equivalent extracellular thirst stimuli (polyethylene glycol) suggesting that important drinking mechanisms are not located in the median eminence.",
author = "Rolls, {Barbara Jean}",
year = "1970",
month = "1",
day = "1",
doi = "10.1016/0031-9384(70)90124-1",
language = "English (US)",
volume = "5",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "12",

}

Drinking by rats after irritative lesions in the hypothalamus. / Rolls, Barbara Jean.

In: Physiology and Behavior, Vol. 5, No. 12, 01.01.1970.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Drinking by rats after irritative lesions in the hypothalamus

AU - Rolls, Barbara Jean

PY - 1970/1/1

Y1 - 1970/1/1

N2 - The deposition of metallic ions in or near the lateral hypothalamus with a stainless-steel anode causes primary polydipsia lasting about six hours. During this time rats are hyperactive and drink as much as two to three times their normal daily intake. This irritative effect accounts for the polydipsia which sometimes follows lesions in the median eminence of the tuber cinereum of nephrectomized rats. Non-irritative lesions there do not cause primary polydipsia. After six hours rats with chronic diabetes insipidus produced by lesions in the median eminence do not show any effects of irritative lesions on water intake. In addition, when their urine output is suppressed these diabetic rats drink almost exactly the amount of water needed to dilute a cellular thirst stimulus (hypertonic saline) to isotonicity and drink the same amount as controls after equivalent extracellular thirst stimuli (polyethylene glycol) suggesting that important drinking mechanisms are not located in the median eminence.

AB - The deposition of metallic ions in or near the lateral hypothalamus with a stainless-steel anode causes primary polydipsia lasting about six hours. During this time rats are hyperactive and drink as much as two to three times their normal daily intake. This irritative effect accounts for the polydipsia which sometimes follows lesions in the median eminence of the tuber cinereum of nephrectomized rats. Non-irritative lesions there do not cause primary polydipsia. After six hours rats with chronic diabetes insipidus produced by lesions in the median eminence do not show any effects of irritative lesions on water intake. In addition, when their urine output is suppressed these diabetic rats drink almost exactly the amount of water needed to dilute a cellular thirst stimulus (hypertonic saline) to isotonicity and drink the same amount as controls after equivalent extracellular thirst stimuli (polyethylene glycol) suggesting that important drinking mechanisms are not located in the median eminence.

UR - http://www.scopus.com/inward/record.url?scp=0014891650&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014891650&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(70)90124-1

DO - 10.1016/0031-9384(70)90124-1

M3 - Article

VL - 5

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 12

ER -