Drug-Induced Liver Disease: Clinical Course

Hemamala Saithanyamurthi, Alison Jazwinski Faust

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Drug-induced liver injury (DILI) is a term used to describe a spectrum of clinical presentations and severity that ranges from mild elevation of liver enzymes on routine blood work to acute liver failure and death. Approximately 10% of all patients with DILI develop acute liver failure resulting in death or liver transplantation. DILI may be prolonged with persistence of elevated liver enzymes for longer than 6 months in approximately 5% to 20% of cases. Cirrhosis and long-term liver-related morbidity and mortality have also been described but are rare, occurring in 1% to 3% of cases.

Original languageEnglish (US)
Pages (from-to)21-34
Number of pages14
JournalClinics in Liver Disease
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2017

All Science Journal Classification (ASJC) codes

  • Hepatology

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