Drugs affecting the cell cycle via actions on the polyamine metabolic pathway.

Joseph M. Ackermann, Anthony Pegg, Diane E. McCloskey

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Polyamines (putrescine, spermidine, and spermine) are ubiquitous cellular components that have multiple functions, including actions affecting the cell cycle. Polyamine biosynthesis and content is altered during the course of cell cycling via changes in two key biosynthetic enzymes, ornithine decarboxylase and S-adenosyl-methionine decarboxylase. Decreases in polyamine content and/or alterations in the relative amounts of polyamines can be achieved by treatment with inhibitors of these enzymes or by application of polyamine analogues, which subvert mechanisms for polyamine homeostasis and may interfere directly with polyamine-dependent processes. Such changes cause G1 and G2-M cell cycle blocks that can be brought about via induction of p21WAF1/CIP1.

Original languageEnglish (US)
Pages (from-to)461-468
Number of pages8
JournalProgress in cell cycle research
Volume5
StatePublished - Jan 1 2003

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Polyamines
Metabolic Networks and Pathways
Cell Cycle
Pharmaceutical Preparations
Ornithine Decarboxylase
Putrescine
Spermidine
Spermine
Enzyme Inhibitors
Homeostasis
Enzymes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "Polyamines (putrescine, spermidine, and spermine) are ubiquitous cellular components that have multiple functions, including actions affecting the cell cycle. Polyamine biosynthesis and content is altered during the course of cell cycling via changes in two key biosynthetic enzymes, ornithine decarboxylase and S-adenosyl-methionine decarboxylase. Decreases in polyamine content and/or alterations in the relative amounts of polyamines can be achieved by treatment with inhibitors of these enzymes or by application of polyamine analogues, which subvert mechanisms for polyamine homeostasis and may interfere directly with polyamine-dependent processes. Such changes cause G1 and G2-M cell cycle blocks that can be brought about via induction of p21WAF1/CIP1.",
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Drugs affecting the cell cycle via actions on the polyamine metabolic pathway. / Ackermann, Joseph M.; Pegg, Anthony; McCloskey, Diane E.

In: Progress in cell cycle research, Vol. 5, 01.01.2003, p. 461-468.

Research output: Contribution to journalReview article

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AU - Pegg, Anthony

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