Dual aptamer-functionalized in situ injectable fibrin hydrogel for promotion of angiogenesis via co-delivery of growth factors

Nan Zhao, Akiho Suzuki, Xiaolong Zhang, Yong Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Introduction: Biomaterials have been extensively used to deliver growth factors for promotion of therapeutic angiogenesis. Among those materials, hydrogels are the most promising delivery vehicle because of their biophysical and biochemical similarity to native tissues [1]. One major drawback of using hydrogel as growth factor delivery system is the quick release of the loaded growth factors due to the high permeability of hydrogels [2]. The burst release of angiogenic growth factors from hydrogel can lead to short therapeutic duration and even toxic effects. In addition, multiple growth factors are needed during the process of angiogenesis, such as vascular endothelial growth factor (VEGF) for initiating the angiogenesis process and platelet derived growth factor (PDGF) for stabilizing newly formed blood vessels [3]. To be able to control the release of multiple angiogenic growth factors from hydrogel system will have the potential to further improve therapeutic angiogenesis.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
Publication statusPublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Zhao, N., Suzuki, A., Zhang, X., & Wang, Y. (2019). Dual aptamer-functionalized in situ injectable fibrin hydrogel for promotion of angiogenesis via co-delivery of growth factors. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.