Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein

Nelson Lezcano, Ladislav Mrzljak, Steven Eubanks, Robert Levenson, Patricia Goldman-Rakic, Clare Bergson

Research output: Contribution to journalArticle

151 Citations (Scopus)

Abstract

The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G(q)- and G(s)-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+(i)) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.

Original languageEnglish (US)
Pages (from-to)1660-1664
Number of pages5
JournalScience
Volume287
Issue number5458
DOIs
StatePublished - Mar 3 2000

Fingerprint

Receptor-Interacting Protein Serine-Threonine Kinases
Dopamine
Receptor Cross-Talk
Prefrontal Cortex
Heterotrimeric GTP-Binding Proteins
Dopamine D1 Receptors
Dendritic Spines
Pyramidal Cells
Cognition
Calcium
calcyon
Proteins

All Science Journal Classification (ASJC) codes

  • General

Cite this

Lezcano, N., Mrzljak, L., Eubanks, S., Levenson, R., Goldman-Rakic, P., & Bergson, C. (2000). Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein. Science, 287(5458), 1660-1664. https://doi.org/10.1126/science.287.5458.1660
Lezcano, Nelson ; Mrzljak, Ladislav ; Eubanks, Steven ; Levenson, Robert ; Goldman-Rakic, Patricia ; Bergson, Clare. / Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein. In: Science. 2000 ; Vol. 287, No. 5458. pp. 1660-1664.
@article{b787685fdc6343bcbab3bc7229842cb9,
title = "Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein",
abstract = "The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G(q)- and G(s)-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+(i)) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.",
author = "Nelson Lezcano and Ladislav Mrzljak and Steven Eubanks and Robert Levenson and Patricia Goldman-Rakic and Clare Bergson",
year = "2000",
month = "3",
day = "3",
doi = "10.1126/science.287.5458.1660",
language = "English (US)",
volume = "287",
pages = "1660--1664",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5458",

}

Lezcano, N, Mrzljak, L, Eubanks, S, Levenson, R, Goldman-Rakic, P & Bergson, C 2000, 'Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein', Science, vol. 287, no. 5458, pp. 1660-1664. https://doi.org/10.1126/science.287.5458.1660

Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein. / Lezcano, Nelson; Mrzljak, Ladislav; Eubanks, Steven; Levenson, Robert; Goldman-Rakic, Patricia; Bergson, Clare.

In: Science, Vol. 287, No. 5458, 03.03.2000, p. 1660-1664.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein

AU - Lezcano, Nelson

AU - Mrzljak, Ladislav

AU - Eubanks, Steven

AU - Levenson, Robert

AU - Goldman-Rakic, Patricia

AU - Bergson, Clare

PY - 2000/3/3

Y1 - 2000/3/3

N2 - The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G(q)- and G(s)-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+(i)) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.

AB - The synergistic response of cells to the stimulation of multiple receptors has been ascribed to receptor cross talk; however, the specific molecules that mediate the resultant signal amplification have not been defined. Here a 24-kilodalton single transmembrane protein, designated calcyon, we functionally characterize that interacts with the D1 dopamine receptor. Calcyon localizes to dendritic spines of D1 receptor-expressing pyramidal cells in prefrontal cortex. These studies delineate a mechanism of G(q)- and G(s)-coupled heterotrimeric GTP-binding protein-coupled receptor cross talk by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+(i)) release as a result of interaction with calcyon. The role of calcyon in potentiating Ca2+-dependent signaling should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex.

UR - http://www.scopus.com/inward/record.url?scp=0034048720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034048720&partnerID=8YFLogxK

U2 - 10.1126/science.287.5458.1660

DO - 10.1126/science.287.5458.1660

M3 - Article

VL - 287

SP - 1660

EP - 1664

JO - Science

JF - Science

SN - 0036-8075

IS - 5458

ER -

Lezcano N, Mrzljak L, Eubanks S, Levenson R, Goldman-Rakic P, Bergson C. Dual signaling regulated by Calcyon, a D1 dopamine receptor interacting protein. Science. 2000 Mar 3;287(5458):1660-1664. https://doi.org/10.1126/science.287.5458.1660