Dural extranodal marginal zone lymphoma in an XRCC2 mutation carrier

Kristina Gvozdjan, Brad E. Zacharia, Michael G. Bayerl, Adeola Tomi-Olugbodi, Cinda Boyer, Charles S. Specht

Research output: Contribution to journalArticle

Abstract

Dural extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a rare entity without an associated recurrent genetic abnormality. Only one case has been described in a woman with history of breast carcinoma without a known genetic predisposition. Here, we report a case of a 56-year-old woman heterozygous for XRCC2 mutation with a history of Graves’ disease and bilateral breast carcinomas, who was found to have a diffusely infiltrative extra-axial mass in the high parietal convexity with infiltration into the adjacent superior sagittal sinus. The morphologic, immunophenotypic, and molecular findings were diagnostic of MALT lymphoma. Staging bone marrow demonstrated involvement by the neoplasm. Although the study was limited to only the clinically significant laboratory evaluation, it may serve as an important addition to the current knowledge of the pathogenic potential of a loss of function mutation in this rarely reported cancer predisposition gene.

Original languageEnglish (US)
Pages (from-to)1174-1177
Number of pages4
JournalJournal of neuropathology and experimental neurology
Volume78
Issue number12
DOIs
StatePublished - Dec 1 2019

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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