Dynamic analysis of a spread cell using finite element method

Hwabok Wee, Arkady Voloshin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The dynamic analysis of a cultured cell using Finite Element Analysis is presented to understand the effect of vibration on a cell structure. The model of a spread cell on a culturing plate has been developed as a continuum model and a cellular tensegrity model. Using Finite Element modal analysis, natural frequencies and mode shapes of both models were obtained and compared with each other. Finite Element harmonic response analysis was carried out to investigate the dynamic response of a spread cell exposed to vibration in the frequency range of 1-60 Hz with 1 G acceleration. Both continuum model and tensegrity model showed that the first three natural frequencies appeared in range of 18 ∼ 27 Hz and they were in the effective vibration frequency range for bone cell growth. In mode 1-3 the major oscillation was observed in horizontal direction and the resonance occurred when the base vibration frequency was closed to the calculated natural frequency. It is presumed that the optimal frequency for bone cell growth is closely related the natural frequency of cell structures and associated with the resonance of cellular structures. For better understanding resonance of cell structure future studies will consider the damping capability of cell structures.

Original languageEnglish (US)
Title of host publicationMechanics of Biological Systems and Materials - Proceedings of the 2013 Annual Conference on Experimental and Applied Mechanics
Pages135-140
Number of pages6
DOIs
StatePublished - 2014
Event2013 Annual Conference on Experimental and Applied Mechanics - Lombard, IL, United States
Duration: Jun 3 2013Jun 5 2013

Publication series

NameConference Proceedings of the Society for Experimental Mechanics Series
Volume4
ISSN (Print)2191-5644
ISSN (Electronic)2191-5652

Other

Other2013 Annual Conference on Experimental and Applied Mechanics
CountryUnited States
CityLombard, IL
Period6/3/136/5/13

All Science Journal Classification (ASJC) codes

  • Engineering(all)
  • Computational Mechanics
  • Mechanical Engineering

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