Dynamic characterization of invasive leader cells during 3D collective cancer invasion

Z. Dean, U. Utzinger, P. K. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study reports a nanobiosensor for dynamic single-cell gene analysis during collective cancer invasion in 3D microenvironments. By incorporating multiphoton microscopy and a 3D cancer invasion assay, we perform dynamic gene expression during cancer invasion and characterize invasive leader cells in 3D microenvironments. Our results underscores the significance of the Notch signaling in the regulation of invasive leader cells during 3D collective cancer invasion.

Original languageEnglish (US)
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages459-460
Number of pages2
ISBN (Electronic)9780979806490
StatePublished - Jan 1 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: Oct 9 2016Oct 13 2016

Publication series

Name20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period10/9/1610/13/16

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

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  • Cite this

    Dean, Z., Utzinger, U., & Wong, P. K. (2016). Dynamic characterization of invasive leader cells during 3D collective cancer invasion. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 459-460). (20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016). Chemical and Biological Microsystems Society.