Dynamic evaluation of a digital wireless intracranial pressure sensor for the assessment of traumatic brain injury in a swine model

Xu Meng, Kevin D. Browne, Shi Min Huang, Constance Mietus, D. Kacy Cullen, Mohammad-reza Tofighi, Arye Rosen

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The monitoring and control of increased intracranial pressure (ICP) are the major requirements for the diagnosis and treatment of patients suffering from traumatic brain injury (TBI) or hydrocephalus. Widely used commercially available ICP measuring devices require the use of a tethered fiber optic probe, which can cause complications, such as infection and hemorrhage. The use of a probe also prohibits immediate (at the time of induced injury) and long-term measurements of ICP. Therefore, we have developed and tested a small fully embedded wireless ICP sensor, incorporating a novel antenna and packaging arrangement. Evaluations were performed in-vitro and in-vivo to demonstrate the robustness of this microwave pressure-monitoring system. This is the first report of in-vivo tests in a dynamic study of continuous (every 6 s) wireless ICP measurements in a swine model of closed-head rotational-acceleration induced TBI using a digital device. In particular, our device measured extreme changes in ICP immediately upon rapid head rotation that persisted for hours after the injury. The readings matched well those obtained from a commercially available tethered monitor. Our device can be utilized in the future as a tool to diagnose and track long-term ICP changes.

Original languageEnglish (US)
Article number6357262
Pages (from-to)316-325
Number of pages10
JournalIEEE Transactions on Microwave Theory and Techniques
Volume61
Issue number1
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Radiation
  • Condensed Matter Physics
  • Electrical and Electronic Engineering

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