Dynamic models of biological pattern formation have some surprising implications for understanding the epigenetics of development

Peter Molenaar, Lawrence Lo

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nonlinear epigenetic processes are conceived of in terms of self-organizing dynamic models of biological pattern formation. Epigenetic processes thus conceived generate substantial subject-specific structural variation, for instance, in growing brain networks. It is shown that standard quantitative genetic modeling based on analyses of interindividual phenotypic variation misclassifies the variation generated by nonlinear epigenetic processes as being due to specific environmental influences. A new quantitative genetic model, iFACE, is introduced to correctly identify the structural variation generated by self-organizing epigenetic processes. iFACE is based on time series analysis of intraindividual variation of a single pair of genetically related subjects. The results of an application of iFACE to multilead EEG obtained with a single dizygotic twin pair is presented.

Original languageEnglish (US)
Title of host publicationAdvances in Child Development and Behavior
PublisherAcademic Press Inc.
Pages21-38
Number of pages18
DOIs
StatePublished - Jan 1 2013

Publication series

NameAdvances in Child Development and Behavior
Volume45
ISSN (Print)0065-2407

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Developmental and Educational Psychology
  • Behavioral Neuroscience

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