Dynamic protein interactions in the bacteriophage T4 replisome

Michael A. Trakselis, M. Uljana Mayer, Faoud T. Ishmael, Rosa Maria Roccasecca, Stephen J. Benkovic

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

The bacteriophage T4 DNA replisome is a complex dynamic system employing a variety of proteins to orchestrate the synthesis of DNA on both the leading and lagging strands. Assembly of the protein complexes responsible for DNA synthesis and priming requires the coordination of transient biomolecular interactions. This interplay of proteins has been dissected through the use of small molecules including fluorescent probes and crosslinkers, enabling the development of a complex dynamic structural and kinetic model for DNA polymerase holoenzyme assembly and primosome formation.

Original languageEnglish (US)
Pages (from-to)566-572
Number of pages7
JournalTrends in Biochemical Sciences
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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