Dynamics of nucleosome assembly and effects of DNA methylation

Ju Yeon Lee, Jaehyoun Lee, Hongjun Yue, Tae Hee Lee

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Background: Nucleosome assembly mediated by histone chaperones and DNA methylation play important roles in gene regulation. Results: Dynamics of nucleosome assembly with and without CpG methylation was investigated. Conclusion: CpG methylation increases the efficiency of nucleosome assembly. Significance: CpG methylation accelerates nucleosome formation that may facilitate gene packaging in chromatin.

Original languageEnglish (US)
Pages (from-to)4291-4303
Number of pages13
JournalJournal of Biological Chemistry
Volume290
Issue number7
DOIs
StatePublished - Feb 13 2015

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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