Background: Nucleosome assembly mediated by histone chaperones and DNA methylation play important roles in gene regulation. Results: Dynamics of nucleosome assembly with and without CpG methylation was investigated. Conclusion: CpG methylation increases the efficiency of nucleosome assembly. Significance: CpG methylation accelerates nucleosome formation that may facilitate gene packaging in chromatin.
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology