Dynamics of the Enterohepatic Circulation of the Glycine Conjugates of Cholic, Chenodeoxycholic, Deoxycholic, and Sulfolithocholic Acid in Man

Gershon W. Hepner, Laurence M. Demers

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Highly sensitive and specific radioimmunoassays for cholylglycine, chenodeoxycholylglycine, deoxycholylglycine, and sulfolithocholylglycine have been used to study the kinetics of the enterohepatic circulation of these conjugated bile acids in 8 healthy subjects. Venous blood samples were collected over a 32-hr period, during which time the subjects ate three meals. Serum levels of cholylglycine and chenodeoxycholylglycine rose after each meal, and reached their maximum level within 30 to 60 min. A second chenodeoxycholylglycine peak occurred 2 to 3 hr after the first two meals in all subjects; a second peak was also found for cholylglycine in 3 of the 8 subjects. Serum deoxycholylglycine levels also rose postprandially; the peak level generally occurred 30 min later than that of cholylglycine. Serum sulfolithocholylglycine levels did not alter significantly after meals. The data indicate that the dynamics of the enterohepatic circulation of individual serum bile acids differ both quantitatively and qualitatively.

Original languageEnglish (US)
Pages (from-to)499-501
Number of pages3
JournalGastroenterology
Volume72
Issue number3
DOIs
StatePublished - 1977

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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