Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?

Craig Eugene Cameron, Ibrahim Moustafa, Jamie Jon Arnold

Research output: Contribution to journalReview article

38 Citations (Scopus)

Abstract

The structural basis for nucleotide incorporation fidelity remains an open question for all nucleic acid polymerases. Addressing this question for the viral RNA-dependent RNA polymerase (RdRp) is of particular, practical significance because it is a determinant of sensitivity to antiviral nucleosides and may be a determinant of viral virulence. All polymerases are thought to employ the same catalytic mechanism, but the rate of nucleotide incorporation can vary substantially. Here we review some of the recent work with the RdRp that leads us to suggest that structure provides only a partial understanding of RdRp function and dynamics may be the missing link.

Original languageEnglish (US)
Pages (from-to)768-774
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume19
Issue number6
DOIs
StatePublished - Dec 1 2009

Fingerprint

RNA Replicase
Viral RNA
Nucleotides
Nucleosides
Nucleic Acids
Antiviral Agents
Virulence

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Structural Biology

Cite this

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title = "Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?",
abstract = "The structural basis for nucleotide incorporation fidelity remains an open question for all nucleic acid polymerases. Addressing this question for the viral RNA-dependent RNA polymerase (RdRp) is of particular, practical significance because it is a determinant of sensitivity to antiviral nucleosides and may be a determinant of viral virulence. All polymerases are thought to employ the same catalytic mechanism, but the rate of nucleotide incorporation can vary substantially. Here we review some of the recent work with the RdRp that leads us to suggest that structure provides only a partial understanding of RdRp function and dynamics may be the missing link.",
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Dynamics : the missing link between structure and function of the viral RNA-dependent RNA polymerase? / Cameron, Craig Eugene; Moustafa, Ibrahim; Arnold, Jamie Jon.

In: Current Opinion in Structural Biology, Vol. 19, No. 6, 01.12.2009, p. 768-774.

Research output: Contribution to journalReview article

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