Dysrhythmias with loperamide used for opioid withdrawal

Nicki D. Vithalani, Christopher Heron, Ravishankar Rao, Anthony F. Cardell, Mark Stephens

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The antidiarrheal loperamide has had a recent, drastic increase in off-label use as an alternative treatment for symptoms of opioid withdrawal. The concept of this is easily discovered on the Internet and social media, where there are multiple blogs and forums promoting loperamide use at doses of 70 to 200 mg per day. Unfortunately, the serious side effects are not well recognized. Multiple cases of cardiac dysrhythmias contributing to death have been highlighted in recent literature. In November 2016, the US Food & Drug Administration released a statement highlighting the potential heart effects and risk of death with high doses of loperamide.1 This case regards a 22-year-old who took 200 mg of loperamide per day for 2 years as an alternative to methadone in her attempts to wean off heroin. Her subsequent spontaneous collapse, dysrhythmias, and acute hospital treatment are reviewed in detail as they were contradictory to standard therapy and required a multidisciplinary approach. Her outpatient management addressed the complex biological, psychological, and social aspects of her addiction.

Original languageEnglish (US)
Pages (from-to)832-834
Number of pages3
JournalJournal of the American Board of Family Medicine
Volume30
Issue number6
DOIs
StatePublished - Nov 1 2017

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Loperamide
Opioid Analgesics
Blogging
Antidiarrheals
Off-Label Use
Social Media
Substance Withdrawal Syndrome
Methadone
Heroin
Internet
Cardiac Arrhythmias
Outpatients
Therapeutics
Psychology
Food
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Family Practice

Cite this

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Dysrhythmias with loperamide used for opioid withdrawal. / Vithalani, Nicki D.; Heron, Christopher; Rao, Ravishankar; Cardell, Anthony F.; Stephens, Mark.

In: Journal of the American Board of Family Medicine, Vol. 30, No. 6, 01.11.2017, p. 832-834.

Research output: Contribution to journalArticle

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