E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions

Amanda Nelson, Zhaoyuan Cong, Samantha L. Gettle, Amy L. Longenecker, Michal Kidacki, Joslyn Sciacca Kirby, David Adams, Douglas Stairs, Frederick W. Danby

Research output: Contribution to journalArticle

Abstract

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease affecting the pilosebaceous units in the axilla, groin and buttocks. While the pathogenesis of HS is not clear, mechanical stress exacerbates HS. In this study, we aimed to determine whether intracellular adhesive junctions may be aberrant in HS patient skin. Strikingly, we observed loss of E-cadherin and p120ctn protein expression, two key adherens junction proteins, in ~85% of HS severe skin lesions. Moreover, loss of protein expression was apparent in non-lesional skin from HS patients and the degree of loss positively correlated with HS Hurley Stage of disease. E-cadherin expression was unaltered in other inflammatory skin conditions including chronic wound epithelium, atopic dermatitis, and acne vulgaris compared with healthy skin suggesting that its loss may be uniquely relevant to HS pathogenesis. A complete loss of α-catenin, β-catenin and ZO-1 was not observed; however, some cytoplasmic staining of the catenins was noted in HS epithelium. We also demonstrated diminished desmosome size in HS lesional skin. Overall, our data suggested that loss of adherens junction proteins and diminished desmosome size in HS skin contributes to the skin's inability to withstand mechanical stress and provides rationale as to why mechanical stress exacerbates HS symptoms.

Original languageEnglish (US)
Pages (from-to)867-871
Number of pages5
JournalExperimental Dermatology
Volume28
Issue number7
DOIs
StatePublished - Jul 1 2019

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Hidradenitis Suppurativa
Cadherins
Skin
Catenins
Proteins
Mechanical Stress
Adherens Junctions
Desmosomes
Jetties
delta catenin
Epithelium
Buttocks
Axilla
Groin
Adhesives
Acne Vulgaris
Atopic Dermatitis
Skin Diseases

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Nelson, Amanda ; Cong, Zhaoyuan ; Gettle, Samantha L. ; Longenecker, Amy L. ; Kidacki, Michal ; Sciacca Kirby, Joslyn ; Adams, David ; Stairs, Douglas ; Danby, Frederick W. / E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions. In: Experimental Dermatology. 2019 ; Vol. 28, No. 7. pp. 867-871.
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E-cadherin and p120ctn protein expression are lost in hidradenitis suppurativa lesions. / Nelson, Amanda; Cong, Zhaoyuan; Gettle, Samantha L.; Longenecker, Amy L.; Kidacki, Michal; Sciacca Kirby, Joslyn; Adams, David; Stairs, Douglas; Danby, Frederick W.

In: Experimental Dermatology, Vol. 28, No. 7, 01.07.2019, p. 867-871.

Research output: Contribution to journalArticle

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AU - Cong, Zhaoyuan

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AU - Adams, David

AU - Stairs, Douglas

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