Early anterior/posterior patterning of the midbrain and cerebellum

A. Liu, A. L. Joyner

Research output: Contribution to journalReview article

188 Citations (Scopus)

Abstract

Transplantation studies performed in chicken embryos indicated that early anterior/posterior patterning of the vertebrate midbrain and cerebellum might be regulated by an organizing center at the junction between the midbrain and hindbrain. More than a decade of molecular and genetic studies have shown that such an organizer is indeed central to development of the midbrain and anterior hindbrain. Furthermore, a complicated molecular network that includes multiple positive and negative feedback loops underlies the establishment and refinement of a mid/hindbrain organizer, as well as the subsequent function of the organizer. In this review, we first introduce the expression patterns of the genes known to be involved in this patterning process and the quail-chick transplantation experiments that have provided the foundation for understanding the genetic pathways regulating mid/hindbrain patterning. Subsequently, we discuss the molecular genetic studies that have revealed the roles for many genes in normal early patterning of this region. Finally, some of the remaining questions and future directions are discussed.

Original languageEnglish (US)
Pages (from-to)869-896
Number of pages28
JournalAnnual Review of Neuroscience
Volume24
DOIs
StatePublished - Aug 11 2001

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Rhombencephalon
Mesencephalon
Cerebellum
Molecular Biology
Transplantation
Quail
Vertebrates
Chickens
Embryonic Structures
Gene Expression
Genes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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abstract = "Transplantation studies performed in chicken embryos indicated that early anterior/posterior patterning of the vertebrate midbrain and cerebellum might be regulated by an organizing center at the junction between the midbrain and hindbrain. More than a decade of molecular and genetic studies have shown that such an organizer is indeed central to development of the midbrain and anterior hindbrain. Furthermore, a complicated molecular network that includes multiple positive and negative feedback loops underlies the establishment and refinement of a mid/hindbrain organizer, as well as the subsequent function of the organizer. In this review, we first introduce the expression patterns of the genes known to be involved in this patterning process and the quail-chick transplantation experiments that have provided the foundation for understanding the genetic pathways regulating mid/hindbrain patterning. Subsequently, we discuss the molecular genetic studies that have revealed the roles for many genes in normal early patterning of this region. Finally, some of the remaining questions and future directions are discussed.",
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Early anterior/posterior patterning of the midbrain and cerebellum. / Liu, A.; Joyner, A. L.

In: Annual Review of Neuroscience, Vol. 24, 11.08.2001, p. 869-896.

Research output: Contribution to journalReview article

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