Early lifecycle UV-exposure calibrates adult vitamin D metabolism

Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes

Mark Lucock, Rohith Thota, Manohar Garg, Charlotte Martin, Patrice Jones, John Furst, Zoe Yates, Nina G. Jablonski, George Chaplin, Martin Veysey, Emma Beckett

Research output: Contribution to journalArticle

Abstract

Objectives: Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long-term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV-exposure on late-life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively). Methods: Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire. Results: Solar irradiance over the first 90 days postconception correlated positively with late-life vitamin D3 (R2 =.0140; P =.0082; β =.1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 =.170; P =.0103; β =.1291) and negatively with the occurrence of female osteoporosis (P =.0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P =.0009). Conclusions: Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.

Original languageEnglish (US)
Article numbere23272
JournalAmerican Journal of Human Biology
Volume31
Issue number4
DOIs
StatePublished - Jul 1 2019

Fingerprint

bone disease
osteoporosis
vitamin
vitamin D
Vitamin D
Osteoporosis
phenotype
metabolism
ergocalciferol
Ergocalciferols
Phenotype
cholecalciferol
Cholecalciferol
First Pregnancy Trimester
evidence
solar radiation
medical history
skeletal development
irradiance
disease models

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

Cite this

Lucock, Mark ; Thota, Rohith ; Garg, Manohar ; Martin, Charlotte ; Jones, Patrice ; Furst, John ; Yates, Zoe ; Jablonski, Nina G. ; Chaplin, George ; Veysey, Martin ; Beckett, Emma. / Early lifecycle UV-exposure calibrates adult vitamin D metabolism : Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. In: American Journal of Human Biology. 2019 ; Vol. 31, No. 4.
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abstract = "Objectives: Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long-term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV-exposure on late-life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively). Methods: Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire. Results: Solar irradiance over the first 90 days postconception correlated positively with late-life vitamin D3 (R2 =.0140; P =.0082; β =.1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 =.170; P =.0103; β =.1291) and negatively with the occurrence of female osteoporosis (P =.0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P =.0009). Conclusions: Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.",
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Early lifecycle UV-exposure calibrates adult vitamin D metabolism : Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. / Lucock, Mark; Thota, Rohith; Garg, Manohar; Martin, Charlotte; Jones, Patrice; Furst, John; Yates, Zoe; Jablonski, Nina G.; Chaplin, George; Veysey, Martin; Beckett, Emma.

In: American Journal of Human Biology, Vol. 31, No. 4, e23272, 01.07.2019.

Research output: Contribution to journalArticle

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T2 - Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes

AU - Lucock, Mark

AU - Thota, Rohith

AU - Garg, Manohar

AU - Martin, Charlotte

AU - Jones, Patrice

AU - Furst, John

AU - Yates, Zoe

AU - Jablonski, Nina G.

AU - Chaplin, George

AU - Veysey, Martin

AU - Beckett, Emma

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N2 - Objectives: Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long-term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This article examines the role of first trimester UV-exposure on late-life vitamin D levels, and potentially related adaptive and maladaptive phenotypes (height and osteoporosis respectively). Methods: Six hundred and forty nine subjects were examined for vitamin D2 and D3 (HPLC) and height (stadiometer). Osteoporosis was assessed with an extensive medical history questionnaire. Results: Solar irradiance over the first 90 days postconception correlated positively with late-life vitamin D3 (R2 =.0140; P =.0082; β =.1075), but not vitamin D2 levels. It also correlated positively with female adult height (R2 =.170; P =.0103; β =.1291) and negatively with the occurrence of female osteoporosis (P =.0495). All data were adjusted for age and gender as appropriate (unadjusted data also provided). From a contemporary perspective, vitamin D levels varied significantly according to season of blood sampling as might be predicted (P =.0009). Conclusions: Increased solar irradiance/UV exposure during the first trimester of pregnancy calibrates adult vitamin D metabolism, which is an important hormone in maintaining calcium balance. This may explain how very early lifecycle UV exposure can influence skeletal development (adult height) and modify risk for the skeletal degenerative disorder osteoporosis. The data demonstrate humans are tuned to the world (exposome) in ways we have not yet fully considered, and which are entrained at the earliest phase of the lifecycle.

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