Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1

Antolin Llorente, Pim Brouwers, Manhattan Charurat, Laurence Magder, Kathleen Malee, Claude Mellins, Janice Ware, Joan Hittleman, Lynne Mofenson, Jesus Velez-Borras, Samuel Adeniyi-Jones

Research output: Contribution to journalArticle

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Abstract

One-hundred and fifty-seven vertically infected HIV-1 positive infants (85 males, 72 females) underwent longitudinal assessment to determine whether early neurodevelopmental markers are useful predictors of mortality in those infants who survive to at least 4 months of age. Survival analysis methods were used to estimate time to death for quartiles of 4-month scores (baseline) on the Bayley Scales of Infant Development (BSID). Cox proportional hazards progression was used to estimate relative hazard (RH, 95% CI) of death for BSID scores and potential confounders. Thirty infants with BSID scores at 4 months of age died during follow-up. Survival analysis revealed greater mortality rates in infants with BSID (Mental Developmental Index and Psychomotor Developmental Index) scores in the lower quartile (p=0.004, p=0.036). Unadjusted univariate analyses revealed increased mortality associated with baseline CD4+ 29%, gestational age <37 weeks, smaller head circumference, advanced HIV and higher plasma viral load. BSID scores independently predicted mortality after adjusting for treatment, clinical category, gestational age, plasma viral load and CD4+ percentage.

Original languageEnglish (US)
Pages (from-to)76-84
Number of pages9
JournalDevelopmental Medicine and Child Neurology
Volume45
Issue number2
StatePublished - Feb 1 2003

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Infant Mortality
Child Development
HIV-1
Mortality
Survival Analysis
Viral Load
Gestational Age
Head
HIV

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neuroscience(all)

Cite this

Llorente, A., Brouwers, P., Charurat, M., Magder, L., Malee, K., Mellins, C., ... Adeniyi-Jones, S. (2003). Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1. Developmental Medicine and Child Neurology, 45(2), 76-84.
Llorente, Antolin ; Brouwers, Pim ; Charurat, Manhattan ; Magder, Laurence ; Malee, Kathleen ; Mellins, Claude ; Ware, Janice ; Hittleman, Joan ; Mofenson, Lynne ; Velez-Borras, Jesus ; Adeniyi-Jones, Samuel. / Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1. In: Developmental Medicine and Child Neurology. 2003 ; Vol. 45, No. 2. pp. 76-84.
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Llorente, A, Brouwers, P, Charurat, M, Magder, L, Malee, K, Mellins, C, Ware, J, Hittleman, J, Mofenson, L, Velez-Borras, J & Adeniyi-Jones, S 2003, 'Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1', Developmental Medicine and Child Neurology, vol. 45, no. 2, pp. 76-84.

Early neurodevelopmental markers predictive of mortality in infants infected with HIV-1. / Llorente, Antolin; Brouwers, Pim; Charurat, Manhattan; Magder, Laurence; Malee, Kathleen; Mellins, Claude; Ware, Janice; Hittleman, Joan; Mofenson, Lynne; Velez-Borras, Jesus; Adeniyi-Jones, Samuel.

In: Developmental Medicine and Child Neurology, Vol. 45, No. 2, 01.02.2003, p. 76-84.

Research output: Contribution to journalArticle

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AU - Magder, Laurence

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AU - Mellins, Claude

AU - Ware, Janice

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AU - Adeniyi-Jones, Samuel

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