Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer

Huan Huan Wang, Lei Deng, Qing Lian Wen, Chun Ze Zhang, Nicholas G. Zaorsky, Bai Lin Zhang, Jie Chen, Xian Liang Zeng, Yao Li Cui, Yang Yang Shi, Hai Ling Hou, Wei Wang, Bo Jiang, Jun Wang, Qing Song Pang, Lu Jun Zhao, Zhi Yong Yuan, Ping Wang, Mao Bin Meng

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Abstract

Aims: The aim of this study was to evaluate the ideal timing of PORT in the management of completely resected (R0) Stage IIIA-N2 NSCLC. Patients and Methods: Between January 2008 and December 2015, patients with known histologies of pathologic Stage IIIA-N2 NSCLC who underwent R0 resection and received PORT concurrent with or prior to two sequential cycles of chemotherapy ("early PORT") or with PORT administered after two cycles of chemotherapy ("late PORT") at multiple hospitals. The primary endpoint was OS; secondary end points included pattern of the first failure, LRRFS, and DMFS. Kaplan-Meier OS, LRRFS, and DMFS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS, LRRFS, and DMFS. Results: Of 112 included patients, 41 (36.6%) and 71 (63.4%) patients received early PORT and late PORT, respectively. The median OS, LRRFS, and DMFS were longer for those who received early PORT than for those who received late PORT at the median follow-up of 29.6 months (all p < 0.05). Uni- and multi-variate analyses showed that number of POCT cycles and the combination schedule of PORT and POCT were independent prognostic factors for OS, LRRFS, and DMFS. Conclusions: Early PORT is associated with improved outcomes in pathologic Stage IIIA-N2 R0 NSCLC patients.

Original languageEnglish (US)
Pages (from-to)62998-63013
Number of pages16
JournalOncotarget
Volume8
Issue number38
DOIs
StatePublished - Jan 1 2017

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Non-Small Cell Lung Carcinoma
Radiotherapy
Drug Therapy
Histology
Appointments and Schedules
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Wang, Huan Huan ; Deng, Lei ; Wen, Qing Lian ; Zhang, Chun Ze ; Zaorsky, Nicholas G. ; Zhang, Bai Lin ; Chen, Jie ; Zeng, Xian Liang ; Cui, Yao Li ; Shi, Yang Yang ; Hou, Hai Ling ; Wang, Wei ; Jiang, Bo ; Wang, Jun ; Pang, Qing Song ; Zhao, Lu Jun ; Yuan, Zhi Yong ; Wang, Ping ; Meng, Mao Bin. / Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer. In: Oncotarget. 2017 ; Vol. 8, No. 38. pp. 62998-63013.
@article{bfe55047c34b4a438ef20ec5df6edd86,
title = "Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer",
abstract = "Aims: The aim of this study was to evaluate the ideal timing of PORT in the management of completely resected (R0) Stage IIIA-N2 NSCLC. Patients and Methods: Between January 2008 and December 2015, patients with known histologies of pathologic Stage IIIA-N2 NSCLC who underwent R0 resection and received PORT concurrent with or prior to two sequential cycles of chemotherapy ({"}early PORT{"}) or with PORT administered after two cycles of chemotherapy ({"}late PORT{"}) at multiple hospitals. The primary endpoint was OS; secondary end points included pattern of the first failure, LRRFS, and DMFS. Kaplan-Meier OS, LRRFS, and DMFS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS, LRRFS, and DMFS. Results: Of 112 included patients, 41 (36.6{\%}) and 71 (63.4{\%}) patients received early PORT and late PORT, respectively. The median OS, LRRFS, and DMFS were longer for those who received early PORT than for those who received late PORT at the median follow-up of 29.6 months (all p < 0.05). Uni- and multi-variate analyses showed that number of POCT cycles and the combination schedule of PORT and POCT were independent prognostic factors for OS, LRRFS, and DMFS. Conclusions: Early PORT is associated with improved outcomes in pathologic Stage IIIA-N2 R0 NSCLC patients.",
author = "Wang, {Huan Huan} and Lei Deng and Wen, {Qing Lian} and Zhang, {Chun Ze} and Zaorsky, {Nicholas G.} and Zhang, {Bai Lin} and Jie Chen and Zeng, {Xian Liang} and Cui, {Yao Li} and Shi, {Yang Yang} and Hou, {Hai Ling} and Wei Wang and Bo Jiang and Jun Wang and Pang, {Qing Song} and Zhao, {Lu Jun} and Yuan, {Zhi Yong} and Ping Wang and Meng, {Mao Bin}",
year = "2017",
month = "1",
day = "1",
doi = "10.18632/oncotarget.18071",
language = "English (US)",
volume = "8",
pages = "62998--63013",
journal = "Oncotarget",
issn = "1949-2553",
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Wang, HH, Deng, L, Wen, QL, Zhang, CZ, Zaorsky, NG, Zhang, BL, Chen, J, Zeng, XL, Cui, YL, Shi, YY, Hou, HL, Wang, W, Jiang, B, Wang, J, Pang, QS, Zhao, LJ, Yuan, ZY, Wang, P & Meng, MB 2017, 'Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer', Oncotarget, vol. 8, no. 38, pp. 62998-63013. https://doi.org/10.18632/oncotarget.18071

Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer. / Wang, Huan Huan; Deng, Lei; Wen, Qing Lian; Zhang, Chun Ze; Zaorsky, Nicholas G.; Zhang, Bai Lin; Chen, Jie; Zeng, Xian Liang; Cui, Yao Li; Shi, Yang Yang; Hou, Hai Ling; Wang, Wei; Jiang, Bo; Wang, Jun; Pang, Qing Song; Zhao, Lu Jun; Yuan, Zhi Yong; Wang, Ping; Meng, Mao Bin.

In: Oncotarget, Vol. 8, No. 38, 01.01.2017, p. 62998-63013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Early postoperative radiotherapy is associated with improved outcomes over late postoperative radiotherapy in the management of completely resected (R0) Stage IIIA-N2 nonsmall cell lung cancer

AU - Wang, Huan Huan

AU - Deng, Lei

AU - Wen, Qing Lian

AU - Zhang, Chun Ze

AU - Zaorsky, Nicholas G.

AU - Zhang, Bai Lin

AU - Chen, Jie

AU - Zeng, Xian Liang

AU - Cui, Yao Li

AU - Shi, Yang Yang

AU - Hou, Hai Ling

AU - Wang, Wei

AU - Jiang, Bo

AU - Wang, Jun

AU - Pang, Qing Song

AU - Zhao, Lu Jun

AU - Yuan, Zhi Yong

AU - Wang, Ping

AU - Meng, Mao Bin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Aims: The aim of this study was to evaluate the ideal timing of PORT in the management of completely resected (R0) Stage IIIA-N2 NSCLC. Patients and Methods: Between January 2008 and December 2015, patients with known histologies of pathologic Stage IIIA-N2 NSCLC who underwent R0 resection and received PORT concurrent with or prior to two sequential cycles of chemotherapy ("early PORT") or with PORT administered after two cycles of chemotherapy ("late PORT") at multiple hospitals. The primary endpoint was OS; secondary end points included pattern of the first failure, LRRFS, and DMFS. Kaplan-Meier OS, LRRFS, and DMFS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS, LRRFS, and DMFS. Results: Of 112 included patients, 41 (36.6%) and 71 (63.4%) patients received early PORT and late PORT, respectively. The median OS, LRRFS, and DMFS were longer for those who received early PORT than for those who received late PORT at the median follow-up of 29.6 months (all p < 0.05). Uni- and multi-variate analyses showed that number of POCT cycles and the combination schedule of PORT and POCT were independent prognostic factors for OS, LRRFS, and DMFS. Conclusions: Early PORT is associated with improved outcomes in pathologic Stage IIIA-N2 R0 NSCLC patients.

AB - Aims: The aim of this study was to evaluate the ideal timing of PORT in the management of completely resected (R0) Stage IIIA-N2 NSCLC. Patients and Methods: Between January 2008 and December 2015, patients with known histologies of pathologic Stage IIIA-N2 NSCLC who underwent R0 resection and received PORT concurrent with or prior to two sequential cycles of chemotherapy ("early PORT") or with PORT administered after two cycles of chemotherapy ("late PORT") at multiple hospitals. The primary endpoint was OS; secondary end points included pattern of the first failure, LRRFS, and DMFS. Kaplan-Meier OS, LRRFS, and DMFS curves were compared with the log-rank test. Cox regression analysis was used to determine prognosticators for OS, LRRFS, and DMFS. Results: Of 112 included patients, 41 (36.6%) and 71 (63.4%) patients received early PORT and late PORT, respectively. The median OS, LRRFS, and DMFS were longer for those who received early PORT than for those who received late PORT at the median follow-up of 29.6 months (all p < 0.05). Uni- and multi-variate analyses showed that number of POCT cycles and the combination schedule of PORT and POCT were independent prognostic factors for OS, LRRFS, and DMFS. Conclusions: Early PORT is associated with improved outcomes in pathologic Stage IIIA-N2 R0 NSCLC patients.

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U2 - 10.18632/oncotarget.18071

DO - 10.18632/oncotarget.18071

M3 - Article

C2 - 28968966

AN - SCOPUS:85029799438

VL - 8

SP - 62998

EP - 63013

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 38

ER -