Eating at the Table of Another: Metabolomics of Host-Parasite Interactions

Björn F.C. Kafsack, Manuel Llinás

Research output: Contribution to journalReview articlepeer-review

54 Scopus citations

Abstract

The application of metabolomics, the global analysis of metabolite levels, to the study of protozoan parasites has become an important tool for understanding the host-parasite relationship and holds promise for the development of direly needed therapeutics and improved diagnostics. Research advances over the past decade have opened the door for a systems biology approach to protozoan parasites with metabolomics, providing a crucial readout of metabolic activity. In this review, we highlight recent metabolomic approaches to protozoan parasites, including metabolite profiling, integration with genomics, transcription, and proteomic analysis, and the use of metabolic fingerprints for the diagnosis of parasitic infections.

Original languageEnglish (US)
Pages (from-to)90-99
Number of pages10
JournalCell Host and Microbe
Volume7
Issue number2
DOIs
StatePublished - Feb 18 2010

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Virology

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