Ectopic ACTH-producing large cell neuroendocrine Pancoast tumour presenting as Horner syndrome

Rajanshu Verma, Alexandra Lambert, Harold H. Katz, Scott J. Benson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We present an interesting case where a patient is presented with a droopy left eyelid (as part of Horner syndrome) and Cushingoid features which were a result of a Pancoast tumour (apical lung tumour in superior pulmonary sulcus) involving the left lung. This tumour was secreting ectopic adrenocorticotropic hormone (ACTH), a paraneoplastic endocrine phenomenon, which resulted in Cushing syndrome symptomatology. Though most ectopic ACTH-producing lung cancers are either small cell or carcinoid tumours, this was in fact a large cell neuroendocrine cancer (LCNEC). Patient underwent surgical resection and adjuvant/neoadjuvant chemotherapy with radiation; however, he succumbed to LCNEC given aggressive nature of the disease.

Original languageEnglish (US)
Article numberbcr-2016-219156
JournalBMJ case reports
Volume2017
DOIs
StatePublished - 2017

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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