Editorial

Age and Non-Invasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: Time to Adjust the Clock?

Jonathan Stine, Mary E. Rinella

Research output: Contribution to journalReview article

Abstract

Despite the widespread prevalence of nonalcoholic fatty liver disease, diagnostic uncertainty of noninvasive tests to detect those with more advanced disease remains an important unmet need. Numerous predictive models have been developed, many of which incorporate age as a covariate. Index derivation studies typically have not included young adults or the elderly and the predictive utility of these models may not be equivalent across the age spectrum. New cutoffs for advanced fibrosis in those >65 have been proposed and validated in a recent study but will require external validation.

Original languageEnglish (US)
Pages (from-to)752-754
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume112
Issue number5
DOIs
StatePublished - May 1 2017

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Uncertainty
Young Adult
Fibrosis
Non-alcoholic Fatty Liver Disease

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

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title = "Editorial: Age and Non-Invasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: Time to Adjust the Clock?",
abstract = "Despite the widespread prevalence of nonalcoholic fatty liver disease, diagnostic uncertainty of noninvasive tests to detect those with more advanced disease remains an important unmet need. Numerous predictive models have been developed, many of which incorporate age as a covariate. Index derivation studies typically have not included young adults or the elderly and the predictive utility of these models may not be equivalent across the age spectrum. New cutoffs for advanced fibrosis in those >65 have been proposed and validated in a recent study but will require external validation.",
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Editorial : Age and Non-Invasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease: Time to Adjust the Clock? / Stine, Jonathan; Rinella, Mary E.

In: American Journal of Gastroenterology, Vol. 112, No. 5, 01.05.2017, p. 752-754.

Research output: Contribution to journalReview article

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