Effect of β β-Tetramethyl-Substituted Hexadecanedioic Acid (Medica 16) on Laying Hen Performance and Egg Yolk Lipid Composition

Robert Glenn Elkin, J. C. Rogler, H. D. Lee, B. A. Watkins

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

P, /T-tetramethyl-substituted hexadecanedioic acid (MEDICA 16), an inhibitor of hepatic cholesterogenesis and lipogenesis in rats, was orally administered to 24-week-old White Leghorn hens for a period of 16 d. Hens were fed maize-soyabean meal diets containing 0, 1–5, or 3–0 g MEDICA 16Aff- Although MEDICA 16 did not affect egg weight, yolk weight, egg cholesterol content, or the efficiency of food utilisation, egg production was significantly reduced in birds fed 3.0 g MEDICA 16/kg compared to those fed the other two diets. Total yolk monounsaturated fatty acids were significantly higher in eggs of hens fed both inclusion rates of MEDICA 16 compared to those of the control birds. In contrast, egg yolk total polyunsaturated fatty acid content and the ratio of polyunsaturated to saturated fatty acids were both inversely related to the dietary content of MEDICA 16. These results suggest that MEDICA 16 primarily altered hepatic fatty acid metabolism, but not cholesterol synthesis, in laying hens.

Original languageEnglish (US)
Pages (from-to)677-681
Number of pages5
JournalBritish Poultry Science
Volume33
Issue number3
DOIs
StatePublished - Jul 1 1992

All Science Journal Classification (ASJC) codes

  • Food Science
  • Animal Science and Zoology

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