Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo

E. J. Ritter, W. J. Scott, J. G. Wilson, B. C. Lampkin, John Neely

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18 Scopus citations

Abstract

5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated tempoerally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.

Original languageEnglish (US)
Pages (from-to)603-605
Number of pages3
JournalJournal of the National Cancer Institute
Volume65
Issue number3
StatePublished - Oct 10 1980

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Ritter, E. J., Scott, W. J., Wilson, J. G., Lampkin, B. C., & Neely, J. (1980). Effect of 5-fluoro-2'-deoxyuridine on deoxyribonucleotide pools in vivo. Journal of the National Cancer Institute, 65(3), 603-605.