5-Fluoro-2'-deoxyuridine (FdUrd) lowered the dTTP levels in rapidly frozen 12-day W rat embryos and in a human neuroblastoma grown in nude N:NIH(S) mice to about 20% of control values. This effect was associated with greatly increased dCTP levels and reduction of dGTP levels essentially to zero. Elimination of the dGTP pool correlated tempoerally with the cytotoxicity of FdUrd. Extremely rapid fixation of tissue was required to avoid artifactually high deoxyribonucleoside triphosphate values.
|Original language||English (US)|
|Number of pages||3|
|Journal||Journal of the National Cancer Institute|
|State||Published - Oct 10 1980|
All Science Journal Classification (ASJC) codes
- Cancer Research